Activating Autophagy Promotes Skin Regeneration Induced by Mechanical Stretch During Tissue Expansion

    January 2024 in “ Burns and trauma ”
    Jing Du, Wei Liu, Yajuan Song … Xianjie Ma
    Studysummary In a rat scalp expansion model, this study found that activating autophagy with rapamycin enhanced skin regeneration during tissue expansion by increasing expanded skin area, epidermis and dermis thicknesses, cell proliferation, angiogenesis, and other regenerative factors, whereas blocking autophagy reversed these effects.
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    Research cited in this study 6

    1. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    2. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    3. Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals Molecular Biology and Evolution · 2018
    4. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018
    5. Development and Homeostasis of the Skin Epidermis Cold Spring Harbor perspectives in biology · 2012
    6. Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells Journal of Cellular Biochemistry · 2009