TLDR Metformin helps improve skin regeneration by increasing the growth of skin stem cells.
The study investigated the effects of topical metformin on skin regeneration in a mechanically stretched scalp model using 20 male rats, divided into metformin-treated (n=10) and control (n=10) groups. The results showed that metformin significantly improved skin regeneration by increasing the thickness of the epidermis and dermis, the number of blood vessels, and the dermal collagen volume fraction. Additionally, there was a notable increase in the number of proliferating cells and stem cells in hair follicles and epidermis in the metformin-treated group. Western blot analysis confirmed increased expression of stem cell markers. The findings suggest that metformin enhances the regenerative capacity of mechanically stretched skin by boosting the proliferative activity of skin-derived stem cells.
27 citations
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January 2019 in “Springer eBooks” Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.
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February 2024 in “Frontiers in bioengineering and biotechnology” Electrospun scaffolds can improve healing in diabetic wounds.