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    Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells

    May 2022 in “ Frontiers in medicine ”
    Shaoheng Xiong, Wei Liu, Yajuan Song … Xianjie Ma
    Studysummary This study found that topical application of metformin significantly enhanced skin regeneration in mechanically stretched skin in rats, likely by boosting the proliferation of skin-derived stem cells.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 6

    1. A Randomized, Controlled Clinical Trial of Autologous Stromal Vascular Fraction Cells Transplantation to Promote Mechanical Stretch-Induced Skin Regeneration Stem Cell Research & Therapy · 2021
    2. Hair Follicle Bulge-Derived Stem Cells Promote Tissue Regeneration During Skin Expansion Biomedicine & Pharmacotherapy · 2020
    3. GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells npj regenerative medicine · 2020
    4. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    5. Macrophages Are Necessary for Skin Regeneration During Tissue Expansion Journal of Translational Medicine · 2019
    6. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018