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Did you mean Lipid Accumulation?

Glossary Lipid Accumulation

excessive fat build-up within cells or tissues

Lipid accumulation, also known as fat accumulation, refers to the build-up of lipids (fats) within cells or tissues. This process can occur in various parts of the body, including the liver, muscles, and skin, and is often associated with metabolic disorders such as obesity, diabetes, and cardiovascular diseases. In the context of hair and alopecia, excessive lipid accumulation in the scalp can potentially disrupt normal hair follicle function, contributing to hair loss.

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research Association between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome

1 citations , February 2016 in “Revista Brasileira de Ginecologia e Obstetrícia”

This study demonstrated a significant association between high lipid accumulation product (LAP) and hirsutism in women with polycystic ovary syndrome (PCOS).

research 1329 Transglutaminase 2 deficiency leads to lipid accumulation and reduced autophagy in SZ95 sebocytes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that tissue transglutaminase (TG2) may play a role in sebum production by regulating autophagy in sebaceous glands, offering potential targets for dermatological interventions.

research 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes

April 2016 in “Journal of Investigative Dermatology”

This study found that trametinib and vemurafenib increased sebum production and gene expression related to lipid accumulation in hamster sebocytes, which may help explain certain side effects in patients.

research Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk

102 citations , July 2007 in “Genes & Development”

This study found that maternal PPARγ is essential for preventing the production of inflammatory lipids in mouse milk, which can otherwise cause inflammation, alopecia, and growth retardation in nursing pups.

research Elevated fasting insulin is associated with cardiovascular and metabolic risk in women with polycystic ovary syndrome

17 citations , May 2019 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews”

This study found that fasting insulin levels are associated with increased cardiovascular and metabolic risk factors in women with polycystic ovary syndrome.

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community Is 2-deoxy-D-ribose (2dDR) good for human hair?

8 upvotes 2 years ago

Topical 2-deoxy-D-ribose (2dDR) regrows hair in mice almost as well as 2% Minoxidil. However, 2dDR may contribute to oxidative stress and hair loss due to the formation of advanced glycation end products (AGEs).

community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 6 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

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