Association Between Lipid Accumulation Product and Hirsutism in Patients with Polycystic Ovary Syndrome

February 2016 in “ Revista Brasileira de Ginecologia e Obstetrícia ”

Flávia R. Oliveira, Mariana Bicalho Rezende, Nícolas Figueiredo Faria, Tomás Ribeiro Gonçalves Dias, Walter Carlos Santos de Oliveira, Ana Luiza Lunardi Rocha, Alexandre Luna Cândido

Polycystic Ovary Syndrome hirsutism Lipid Accumulation Product Ferriman-Gallwey index HDL cholesterol BMI Metabolic Syndrome insulin resistance cardiovascular risk PCOS LAP FGI body mass index

TLDR High Lipid Accumulation Product levels are linked to more hirsutism in women with Polycystic Ovary Syndrome.

In 2016, a study involving 263 patients with Polycystic Ovary Syndrome (PCOS) found a significant association between Lipid Accumulation Product (LAP) and hirsutism. High LAP was observed in 67.3% of the patients, and hirsutism, measured by the Ferriman-Gallwey index (FGI), was present in 58.5%. A positive correlation was noted, especially in the highest LAP quartile, indicating that a high LAP could be linked to increased cardiovascular risk in these patients. Additionally, those with altered LAP had lower HDL cholesterol levels, higher BMI, and more Metabolic Syndrome criteria. Women in the upper LAP quartile had a 2-fold higher association with altered FGI, suggesting that hirsutism in PCOS is related to insulin resistance and cardiovascular risk. The study suggests that the FGI could be a cost-effective tool for assessing cardiovascular risk in women with PCOS.

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