Clinical Usefulness of Non-Invasive Metabolic-Associated Fatty Liver Disease Risk Assessment Methods in Patients with Polycystic Ovary Syndrome in Relation to MRI Examination with the Ideal IQ Sequence

    September 2022 in “ Biomedicines ”
    Łukasz Blukacz, Artur Nowak, Mariusz Wójtowicz, Angelika Krawczyk, Grzegorz Franik, Paweł Madej, Dagmara Pluta, Karolina Kowalczyk, Michał Żorniak
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    Studysummary This study found that lipid accumulation product (LAP) and free androgen index (FAI) can highly predict liver steatosis in women with PCOS phenotype A.
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    The study conducted on 49 women with Polycystic Ovary Syndrome (PCOS) found that Lipid Accumulation Product (LAP) and Free Androgens Index (FAI) are effective non-invasive methods for assessing the risk of Metabolic-Associated Fatty Liver Disease (MAFLD). A LAP value over 70.25 and a FAI value over 5.05 were associated with liver steatosis, with women having LAP > 70.25 and FAI > 5.05 at 4.07 to 80.38 and 3.04 to 45.27 times higher risk of liver steatosis respectively. However, Sex Hormone-Binding Globulin (SHBG), a component of FAI, was not a significant predictor of liver steatosis. These findings suggest that LAP and FAI can be used to diagnose liver steatosis in women with PCOS, where MAFLD prevalence is around 30-70%.
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