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research 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents

93 citations , September 2014 in “Diabetes”

This study found that male 5αR1 knockout mice and obese Zucker rats treated with finasteride showed increased insulin resistance and hepatic steatosis, potentially implicating 5α-reductase activity in metabolic liver disease development.

Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature

research Progressive Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) from a Young Age Due to a Rare Genetic Disorder, Familial Partial Lipodystrophy: A Case Report and Review of the Literature

December 2024 in “Livers”

This case report highlights a female patient with familial partial lipodystrophy who showed significant improvement in liver stiffness after starting leptin replacement therapy.

research S2926 Hepatic Steatosis and Acute Liver Injury in Chronic Arsenic Exposure

1 citations , October 2022 in “The American Journal of Gastroenterology”

This case study describes a 29-year-old woman whose severe liver injury was primarily attributed to chronic arsenic exposure, highlighting the importance of recognizing metal toxicity in patient care.

Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Androgenetic Alopecia in Adults With Stronger Effects in Women and Unhealthy Lifestyles

research Metabolic dysfunction-associated steatotic liver disease is associated with androgenetic alopecia in adults with stronger effects in women and unhealthy lifestyles

November 2025 in “Scientific Reports”

This study found that metabolic dysfunction-associated steatotic liver disease is linked to a higher risk of androgenetic alopecia, especially in women and individuals with certain lifestyle patterns.

research S4309 Khat-Associated Liver Injury in Yemeni Male With Hepatic Steatosis

1 citations , October 2024 in “The American Journal of Gastroenterology”

In this case report, a 42-year-old Yemeni man who consumed khat presented with elevated liver enzymes and fatty liver, raising concerns about khat's potential role in accelerating liver damage, especially when obesity and fatty liver disease are already present.

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community How much would a high dose dutasteride scalp dht inhibition be?

in Finasteride/Dutasteride 10 upvotes 2 years ago

The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.

community Bad experience at Dermatologist

43 upvotes 4 years ago

A user had a disappointing dermatologist appointment where they were denied prescriptions for Dutasteride and oral Minoxidil for hair loss and were only offered a hair transplant referral. Other users sympathized, discussed self-medication, and suggested consulting a transplant doctor for up-to-date treatments.

community if Post Finasteride Syndrome is real. Why is it only the negative effects and not positive have log term effect?

in Finasteride/Dutasteride 63 upvotes 4 months ago

Finasteride is used for hair loss, with mixed reports of no side effects and claims of long-term negative effects known as Post Finasteride Syndrome (PFS). The conversation debates the existence and causes of PFS, with differing opinions on whether it is psychological or real.

community No motivation to workout because I’ll be bald no matter what

in Chat 78 upvotes 1 year ago

The conversation is about hair loss affecting motivation to work out. The original poster is using dutasteride and minoxidil and is considering a hair transplant.

community liver problem from finasteride/dutasteride

13 upvotes 3 years ago

The conversation discusses liver issues potentially linked to long-term use of finasteride and dutasteride, with users sharing similar experiences of elevated liver enzymes, high cholesterol, and other health concerns. The consensus suggests stopping the medication and consulting a healthcare professional for proper diagnosis and treatment.

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