The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study

March 2022 in “ Frontiers in Endocrinology ”

Mahbanoo Farhadi-Azar, Samira Behboudi‐Gandevani, Maryam Rahmati, Fatemeh Mahboobifard, Ensi Khalili Pouya, Fahimeh Ramezani Tehrani, Fereidoun Azizi

Polycystic Ovary Syndrome PCOS phenotype B oligo/anovulatory dysfunction hyperandrogenism total testosterone androstenedione DHEAS free androgen index testosterone

TLDR About 19.4% of Iranian women in the study have Polycystic Ovary Syndrome, with the most common type involving irregular periods and high male hormone levels, but their heart and metabolic health is similar to women without the condition.

The study, which included 1,960 Iranian women, found that Polycystic Ovary Syndrome (PCOS) is prevalent in 19.4% of the participants. The most common phenotype was phenotype B, characterized by oligo/anovulatory dysfunction and hyperandrogenism. Women with PCOS had higher serum levels of total testosterone, androstenedione, DHEAS, and free androgen index compared to healthy women. However, there were no significant differences in BMI, WC, HC, WHR, WHtR, and ABSI between PCOS and healthy subjects after adjusting for age and BMI. The cardio-metabolic profile of women with PCOS was similar to healthy women. The study suggests that routine screening for metabolic disturbances may be needed in the prevention of cardio-metabolic disorders in patients with more serious phenotypes of PCOS.

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