Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

August 2020 in “ Frontiers in Endocrinology ”

Antônio Aversa, Sandro La Vignera, Rocco Rago, Alessandra Gambineri, Rossella E. Nappi, Aldo E. Calogero, Alberto Ferlin

polycystic ovary syndrome PCOS endocrine disorder metabolic disorder gestational diabetes nutraceutical therapy

Studysummary This review discusses expert consensus on PCOS, emphasizing its impacts and supporting evidence-based treatments, while recommending further research into nutraceutical benefits for managing the condition; it reports no new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

308 citations , December 2018 in “PLOS Genetics”

This study identified three novel genetic loci associated with PCOS and found similar genetic architecture across different diagnostic criteria, with evidence suggesting genetic links between PCOS and various metabolic and psychological traits.

research Polycystic Ovary Syndrome: Comprehensive Overview

257 citations , July 2018 in “Obstetrics & Gynecology”

This review discusses the various phenotypes and diagnostic challenges of polycystic ovary syndrome, highlighting its complex pathophysiology and associated health risks, and reports no new clinical results.

research Anxiety, Depression, and Quality of Life in Women with Polycystic Ovarian Syndrome

60 citations , May 2018 in “Indian Journal of Psychological Medicine”

This article highlights the lack of attention to the impact of polycystic ovarian syndrome on women's identity, mental health, and quality of life in India without offering new findings.

research Glycolipid and Hormonal Profiles in Young Men with Early-Onset Androgenetic Alopecia: A Meta-Analysis

15 citations , August 2017 in “Scientific Reports”

This study found that young men with early-onset androgenetic alopecia have a worse glycolipid profile and hormone pattern similar to women's PCOS, suggesting a possible male PCOS-equivalent syndrome.

research Does a Male Polycystic Ovarian Syndrome Equivalent Exist?

28 citations , July 2017 in “Journal of Endocrinological Investigation”

This study suggests that early onset androgenetic alopecia in men may indicate a male PCOS equivalent, possibly leading to higher risks of metabolic and cardiovascular disorders later in life.

research 5α-Reductase Activity in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

20 citations , March 2017 in “Reproductive Biology and Endocrinology”

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

research Normal Pubertal Development in Daughters of Women With PCOS: A Controlled Study

27 citations , October 2016 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, daughters of women with PCOS and control daughters showed no significant differences in metabolic and hormonal parameters, but more PCOS daughters exhibited hirsutism at advanced pubertal stages.

research Comprehensive Overview of Polycystic Ovary Syndrome

883 citations , August 2016 in “Nature Reviews Disease Primers”

This review discusses the current understanding of polycystic ovary syndrome, focusing on its epidemiology, pathophysiology, diagnosis, management, and future research directions, but reports no new clinical results.

research Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome

40 citations , March 2016 in “The Journal of Clinical Endocrinology & Metabolism”

This study suggests that daughters of women with PCOS may have altered androgen metabolism in early childhood, with increased 5α-reductase activity potentially contributing to PCOS development.

research Evaluation of Affective Temperament and Anxiety–Depression Levels of Patients with Polycystic Ovary Syndrome

35 citations , July 2015 in “Journal of Affective Disorders”

This study found that women with polycystic ovary syndrome have significantly higher scores for affective temperaments and anxiety and depression than healthy controls, suggesting risk for depressive and anxiety disorders.

research Psychological Aspects of Hyperandrogenic States in Late Adolescent and Young Women

30 citations , March 2015 in “Clinical Endocrinology”

This study found that late adolescent and young women with clinical hyperandrogenism, including PCOS, experienced higher psychological distress and impaired well-being compared to their healthy peers.

research The Polycystic Ovary Syndrome: A Position Statement from the European Society of Endocrinology

467 citations , October 2014 in “European Journal of Endocrinology”

This paper reviews the diagnostic criteria, etiological factors, and treatment approaches for PCOS, highlighting the importance of considering metabolic issues such as insulin resistance and obesity, but reports no new findings.

research Alopecia and Its Association with Coronary Heart Disease and Cardiovascular Risk Factors: A Meta-Analysis

48 citations , October 2014 in “International Journal of Cardiology”

This meta-analysis found that people with alopecia have an increased risk of coronary heart disease and several cardiovascular risk factors compared to those without alopecia.

research Potential Role and Therapeutic Interests of Myo-Inositol in Metabolic Diseases

369 citations , June 2013 in “Biochimie”

This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.

research Association of Androgenetic Alopecia With Mortality From Diabetes Mellitus and Heart Disease

49 citations , May 2013 in “JAMA Dermatology”

This study found that moderate to severe androgenetic alopecia is an independent predictor of increased mortality risk from diabetes mellitus and heart disease in both sexes.

Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

research Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

1514 citations , December 2011 in “Fertility and sterility”

This consensus report reviews current knowledge and identifies knowledge gaps concerning the various health aspects of polycystic ovary syndrome, without presenting new clinical findings.

Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36

research Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Comparison with the General Population Using the Polycystic Ovary Syndrome Questionnaire and the Short Form-36

167 citations , January 2006 in “Gynecological Endocrinology”

This study found that women with polycystic ovary syndrome reported a poorer health-related quality of life compared to women in the general population and patients with other medical conditions.

research What May Be the Markers of the Male Equivalent of Polycystic Ovary Syndrome?

39 citations , January 2004 in “Physiological Research”

In this study, researchers reported that about one-third of men with premature alopecia displayed hormonal shifts and higher insulin resistance, resembling the prevalence pattern of PCOS in women.