Polycystic Ovary Syndrome Is Associated With NASH Severity And Advanced Fibrosis

    October 2019 in “ Liver International ”
    Monika Sarkar, Norah A. Terrault, Wesley Chan, Marcelle I. Cedars, Heather G. Huddleston, Caroline C. Duwaerts, Dana Balitzer, Ryan M. Gill
    TLDR Women with PCOS have more severe liver disease.
    The study concluded that Polycystic Ovary Syndrome (PCOS) was significantly associated with more severe Non-Alcoholic Steatohepatitis (NASH) and advanced fibrosis in women. Among 102 women with biopsy-confirmed non-alcoholic fatty liver disease (NAFLD), 36% had PCOS and exhibited higher LDL levels, BMI, and a higher prevalence of severe hepatocyte ballooning and advanced fibrosis. Adjusted analyses confirmed significant associations between PCOS and severe hepatocyte ballooning (OR 3.4, p=0.03) and advanced fibrosis (OR 7.1, p=0.02). The findings suggested that PCOS could be a risk factor for severe liver disease, emphasizing the need for hepatologists to routinely inquire about PCOS in women with NAFLD and evaluate for more severe liver conditions in this population.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 12 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 2 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community C’est terrible - at my wits end

      in Female  449 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Why balding gets worse in every generation?

      in Chat  81 upvotes 4 months ago
      Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

    Similar Research

    5 / 1000+ results