Polycystic Ovary Syndrome Is Associated With NASH Severity And Advanced Fibrosis

November 2019 in “ Liver International ”

Monika Sarkar, Norah A. Terrault, Wesley Chan, Marcelle I. Cedars, Heather G. Huddleston, Caroline C. Duwaerts, Dana Balitzer, Ryan M. Gill

polycystic ovary syndrome PCOS non-alcoholic steatohepatitis NASH advanced fibrosis non-alcoholic fatty liver disease NAFLD LDL BMI hepatocyte ballooning

TLDR Women with PCOS have more severe liver disease.

The study concluded that Polycystic Ovary Syndrome (PCOS) was significantly associated with more severe Non-Alcoholic Steatohepatitis (NASH) and advanced fibrosis in women. Among 102 women with biopsy-confirmed non-alcoholic fatty liver disease (NAFLD), 36% had PCOS and exhibited higher LDL levels, BMI, and a higher prevalence of severe hepatocyte ballooning and advanced fibrosis. Adjusted analyses confirmed significant associations between PCOS and severe hepatocyte ballooning (OR 3.4, p=0.03) and advanced fibrosis (OR 7.1, p=0.02). The findings suggested that PCOS could be a risk factor for severe liver disease, emphasizing the need for hepatologists to routinely inquire about PCOS in women with NAFLD and evaluate for more severe liver conditions in this population.

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American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

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The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

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The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations, January 2004 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.