Polycystic Ovary Syndrome, Androgen Excess, and the Risk of Nonalcoholic Fatty Liver Disease in Women: A Longitudinal Study Based on a United Kingdom Primary Care Database

    March 2018 in “ PLOS Medicine ”
    Balachandran Kumarendran, Michael O’Reilly, K. Manolopoulos … Krishnarajah Nirantharakumar
    Studysummary This study found that women with polycystic ovary syndrome have higher rates of nonalcoholic fatty liver disease, with androgen excess contributing to the risk.
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    Research cited in this study 8

    1. The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Human Reproduction · 2016
    2. Prevalence of Non-Alcoholic Fatty Liver Disease in Women with Polycystic Ovary Syndrome and Its Correlation with Metabolic Syndrome Arquivos De Gastroenterologia · 2015
    3. 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes Endocrinology · 2015
    4. Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group Fertility and sterility · 2011
    5. Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society The Journal of Clinical Endocrinology & Metabolism · 2010
    6. Increased Androgen Bioavailability Is Associated With Non-Alcoholic Fatty Liver Disease In Women With Polycystic Ovary Syndrome Human Reproduction · 2009
    7. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004
    8. Polycystic Ovary Syndrome: Clinical and Biochemical Features New England journal of medicine/˜The œNew England journal of medicine · 1995