The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome

April 2018 in “ Current opinion in gynecology and obstetrics ”

Monika Sarkar, Norah A. Terrault, Caroline C. Duwaerts, Phyllis C. Tien, Marcelle I. Cedars, Heather G. Huddleston

Polycystic Ovary Syndrome PCOS nonalcoholic fatty liver disease NAFLD nonalcoholic steatohepatitis NASH hepatic steatosis insulin resistance

Studysummary The study observed that Hispanic women with PCOS had significantly higher odds of having NASH compared to non-Hispanic women, suggesting routine screening may be beneficial in this high-risk group.

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The study conducted on 303 women with Polycystic Ovary Syndrome (PCOS) found that Hispanic women had a significantly higher prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The study found that 83% of Hispanic women had hepatic steatosis, compared to 24% of non-Hispanics. Hispanic ethnicity was associated with two-fold higher odds of NASH, and this association persisted even after adjusting for insulin resistance and waist circumference. The study concluded that Hispanic women with PCOS are a high-risk group for NAFLD/NASH and may benefit from routine screening.

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