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    Glossary FOXC2

    gene involved in tissue development and hair follicle regulation

    FOXC2 is a gene that encodes a protein involved in the development and function of various tissues, including the formation of blood vessels and the regulation of fat storage. Mutations in FOXC2 can lead to conditions like lymphedema-distichiasis syndrome, which is characterized by swelling due to fluid retention and the presence of extra eyelashes. This gene also plays a role in hair follicle development and can impact hair growth and health.

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    Research 30 of 265

    1. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells Science · 2016 · 142 citations
    2. Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes Frontiers in Cell and Developmental Biology · 2020 · 5 citations
    3. Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia Experimental Cell Research · 2021
    4. Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 2 citations
    5. Aging, alopecia, and stem cells Science · 2016 · 42 citations
    6. Identification of Potential Hub Genes in Alopecia Areata Experimental Dermatology · 2024 · 4 citations
    7. Finding bald spots on chromosome 20p11 Clinical Genetics · 2009 · 1 citations
    8. A Theoretical Model for the Treatment of Androgenetic Alopecia Using the STEAP3 Protein, and the Genetic Challenges of Treating AGA Health Science Reports · 2026
    9. In Silico Promoter Motif Analysis of Human Fertility-Related Genes Applied Biosciences · 2026
    10. Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration Digital Commons - RU (Rockefeller University) · 2025
    11. Melatonin-Mediated Circadian Rhythm Signaling Exhibits Bidirectional Regulatory Effects on the State of Hair Follicle Stem Cells Biomolecules · 2025
    12. Di-Genic Inheritance in Genodermatoses: Insights from Two Consanguineous Cases in a Reference Lebanese Center within the Middle East and North Africa (MENA) Region Dermatology Practical & Conceptual · 2025
    13. Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis Frontiers in Cell and Developmental Biology · 2025
    14. Topical Finasteride: A Comprehensive Review of Androgenetic Alopecia Management for Men and Women Cureus · 2023
    15. 1438 KLF4 maintains hair follicle stem cell quiescence 2023
    16. Genetic Defects of Female Sexual Differentiation Elsevier eBooks · 2016
    17. Quiescent and aging hair follicle stem cells Science · 2016
    18. Cell-intrinsic mechanisms governing stem cell quiescence and regulating cancer progression in mammalian skin CU Scholar (University of Colorado Boulder) · 2015
    19. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    20. Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    21. Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    22. Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    23. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Science · 2016 · 242 citations
    24. Quiescent Tissue Stem Cells Evade Immune Surveillance Immunity · 2018 · 169 citations
    25. Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses Cancer Research Communications · 2024 · 7 citations
    26. Multiple cell types guided by neurocytes orchestrate horn bud initiation in dairy goats Genetics Selection Evolution · 2025 · 1 citations
    27. Editor's evaluation: Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness 2022
    28. TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris 2026
    29. Prediction of male-pattern baldness from genotypes European Journal of Human Genetics · 2015 · 37 citations
    30. A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions Human Genetics · 2019 · 10 citations