Cholesterol Homeostasis in Hair Follicle Keratinocytes Is Disrupted by Impaired ABCA5 Activity
June 2023
in “
Biochimica and biophysica acta. Molecular and cell biology of lipids
”
cholesterol homeostasis hair follicle keratinocytes ABCA5 ABC transporter family cholesterol transport outer root sheath keratinocytes siRNA-mediated knockdown cholesterol levels endo-lysosomes ER mitochondria hair follicle morphogenesis hair growth hair cycling hypertrichosis cholesterol balance hair follicle cells ABCA5 protein ABC transporters cholesterol movement ORS keratinocytes siRNA knockdown cholesterol concentration endosomes endoplasmic reticulum hair development hair production hair cycle excessive hair growth
TLDR Impaired ABCA5 activity disrupts cholesterol balance in hair follicle cells, affecting hair growth.
The study "Cholesterol homeostasis in hair follicle keratinocytes is disrupted by impaired ABCA5 activity" investigates the role of ABCA5, a member of the ABC transporter family, in cholesterol transport and homeostasis in outer root sheath (ORS) keratinocytes of hair follicles. The researchers found that ABCA5 protein localization can be modulated by changes in cellular cholesterol levels, which also altered intracellular co-localization to endo-lysosomes, ER, and mitochondria. Using siRNA-mediated knockdown, ABCA5 was implicated in the maintenance of cholesterol. This study provides deeper insight into the potential roles of ABCA5 in cholesterol transport and homeostasis in ORS keratinocytes, which is important for normal hair follicle morphogenesis, growth, and cycling. Disruption of cholesterol homeostasis may have a profound impact on hair follicle biology, which could explain the link between ABCA5 mutation and hypertrichosis, a condition characterized by excessive hair growth.
