Cholesterol Homeostasis in Hair Follicle Keratinocytes Is Disrupted by Impaired ABCA5 Activity

    June 2023 in “ Biochimica and biophysica acta. Molecular and cell biology of lipids ”
    Megan A. Palmer, Irundika H.K. Dias, Eleanor Smart … Iain S. Haslam
    Studysummary In this study, researchers found that knockdown of ABCA5 in primary human hair follicle keratinocytes disrupted cholesterol homeostasis and transportation, suggesting its potential role in hair growth disorders by affecting intracellular cholesterol compartmentalization and LXR-mediated transcriptional activity.
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    Research cited in this study 21

    1. Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle Histochemistry and Cell Biology · 2021
    2. Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders Experimental Dermatology · 2019
    3. Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland Experimental Dermatology · 2018
    4. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    5. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    6. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    7. Atherogenic Index of Plasma in Non-Obese Women with Androgenetic Alopecia International Journal of Dermatology · 2015
    8. Is Early Onset Androgenic Alopecia a Marker of Metabolic Syndrome and Carotid Artery Atherosclerosis in Young Indian Male Patients? International Journal of Trichology · 2015
    9. Differential Expression and Functionality of ATP-Binding Cassette Transporters in the Human Hair Follicle British Journal of Dermatology · 2014
    10. Association of Premature Androgenetic Alopecia and Metabolic Syndrome in a Young Indian Population International Journal of Trichology · 2014
    11. Association Between Androgenetic Alopecia and Coronary Artery Disease in Young Male Patients International Journal of Trichology · 2014
    12. Sex Steroid Synthesis in Human Skin In Situ: The Roles of Aromatase and Steroidogenic Acute Regulatory Protein in the Homeostasis of Human Skin Molecular and Cellular Endocrinology · 2012
    13. The Association of Insulin Resistance and Metabolic Syndrome in Early Androgenetic Alopecia PubMed · 2010
    14. Lipid Levels in Women with Androgenetic Alopecia International Journal of Dermatology · 2010
    15. Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study Journal of The American Academy of Dermatology · 2010
    16. Male Androgenetic Alopecia and Cardiovascular Risk Factors: A Case-Control Study Actas Dermo-Sifiliográficas · 2010
    17. A Comparative Study of Dyslipidemia in Men and Women with Androgenic Alopecia Acta dermato-venereologica · 2010
    18. A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control ˜The œAmerican journal of pathology (Print) · 2005
    19. Human Skin Is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1) Journal of Investigative Dermatology · 2003
    20. The Risk of Coronary Heart Disease in Men with Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 1999
    21. Studies on the Biochemistry and Morphology of Freshly Isolated and Maintained Rat Hair Follicles Journal of Cell Science · 1989

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    3. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    4. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981