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GlossaryATP-Binding Cassette Transporters (ABC transporters)

proteins that use ATP to move molecules across cell membranes

ATP-Binding Cassette (ABC) Transporters are a large family of proteins that use the energy from ATP (adenosine triphosphate) to transport various molecules across cellular membranes. These transporters play crucial roles in processes like drug resistance, lipid transport, and the movement of metabolic products, making them essential for maintaining cellular function and homeostasis.

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research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle

24 citations, November 2013 in “Trends in pharmacological sciences”

Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

research Differential Expression and Functionality of ATP-Binding Cassette Transporters in the Human Hair Follicle

25 citations, November 2014 in “British Journal of Dermatology”

Certain transporters are found in human hair follicles and may affect hair growth and loss.

research Untargeted Metabolomics Analysis of Plasma Metabolic Characteristics in Patients With Acne and Insulin Resistance

May 2023 in “Research Square (Research Square)”

Patients with acne and insulin resistance have different blood metabolites compared to those with only acne, which could help in diagnosis and treatment.

Molecular Phenotyping of Lichen Planopilaris Revealed Dysregulation of Cholesterol/Fatty Acid Metabolism, Fibrosis, and Mast Cell Pathways

research Molecular Phenotyping of Lichen Planopilaris Revealed Dysregulation of Cholesterol/Fatty Acid Metabolism, Fibrosis, and Mast Cell Pathways

April 2019 in “Journal of Investigative Dermatology”

Lichen planopilaris involves disrupted fat metabolism, increased scarring, and mast cell activity.

research Absorption Sites of Orally Administered Drugs in the Small Intestine

55 citations, September 2017 in “Expert Opinion on Drug Discovery”

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

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community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 149 upvotes 6 months ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.