Sox13 Is a Novel Early Marker for Hair Follicle Development

January 2019 in “ Biochemical and Biophysical Research Communications ”

Mai Noto, Natsuko Noguchi, Akihiko Ishimura, Hiroshi Kiyonari, Takaya Abe, Tomoko Suzuki, Naoko Hasunuma, Masanori Taira, Motomu Manabe, Shin‐Ichi Osada

Sox13 hair follicle development epithelial portion placode hair germ hair peg outer root sheath catagen phase anagen phase bulge region telogen phase hair follicle stem cells hair follicle stem cells

TLDR Sox13 is a useful marker for early hair follicle development but not essential for hair growth.

The study identified Sox13 as a novel early marker for hair follicle development. Sox13 was expressed in the epithelial portion of the placode, hair germ, and hair peg during early development stages. In postnatal stages, Sox13 was found in the outer root sheath during catagen and anagen phases, and in the bulge region during telogen, where hair follicle stem cells reside. Despite its expression patterns, Sox13 was found to be dispensable for epidermal and adnexal development, as Sox13-deficient mice showed no significant differences compared to wild-type mice. This suggests that while Sox13 is not essential for hair development, it serves as a useful marker for studying early hair follicle formation.

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