Sox13 Is a Novel Early Marker for Hair Follicle Development

    January 2019 in “ Biochemical and Biophysical Research Communications ”
    Mai Noto, Natsuko Noguchi, Akihiko Ishimura, Hiroshi Kiyonari, Takaya Abe, Tomoko Suzuki, Naoko Hasunuma, Masanori Taira, Motomu Manabe, Shin‐Ichi Osada
    Studysummary This study suggests that Sox13, although dispensable for epidermal development, serves as a marker for early hair follicle development in Sox13-LacZ knock-in mice.
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    The study identified Sox13 as a novel early marker for hair follicle development. Sox13 was expressed in the epithelial portion of the placode, hair germ, and hair peg during early development stages. In postnatal stages, Sox13 was found in the outer root sheath during catagen and anagen phases, and in the bulge region during telogen, where hair follicle stem cells reside. Despite its expression patterns, Sox13 was found to be dispensable for epidermal and adnexal development, as Sox13-deficient mice showed no significant differences compared to wild-type mice. This suggests that while Sox13 is not essential for hair development, it serves as a useful marker for studying early hair follicle formation.
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