Analysis of Hair Follicles in Mutant Laboratory Mice

November 2005 in “ The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings ”

John P. Sundberg, Eva M.J. Peters, Ralf Paus

hair follicles pilosebaceous units

Studysummary This article reviews the anatomical complexity and developmental aspects of hair follicles for analyzing abnormalities, but reports no new clinical findings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on jidsponline.org →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Making Waves with Hairs: Genetic and Epigenetic Factors in Hair Pattern Formation

18 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review explores the potential genetic and epigenetic influences on hair whorl patterns and suggests that pattern formation may involve basic physical-chemical laws, although it reports no new experimental findings.

research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss

37 citations , November 2003 in “Veterinary pathology”

This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.

research Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model

107 citations , September 2002 in “Journal of Investigative Dermatology”

This study identified a distinct "exogen" phase in the hair cycle during which hair shedding occurs, primarily coupled with the anagen phase, rather than as part of the telogen phase.

research Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice

86 citations , May 2002 in “Journal of comparative neurology”

This study observed that hair follicle innervation in C57BL/6 mice occurs in sequential stages that closely correlate with the development of hair follicles, indicating an interdependent relationship between neuronal and epithelial morphogenesis.

The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

146 citations , May 2002 in “The American journal of pathology”

This study found that cathepsin L deficiency in mice led to significant abnormalities in hair follicle development and cycling, including disrupted hair shaft outgrowth and premature hair growth phase entry.

research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables

86 citations , December 2001 in “Experimental dermatology”

This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.

research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides

112 citations , February 2001 in “Journal of Investigative Dermatology”

This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.

research A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression

96 citations , October 2000 in “The FASEB Journal”

In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.

research Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?

130 citations , December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, different types of catagen in the C57BL/6 mouse model exhibited varying effects on hair follicle melanocytes and melanin distribution, with spontaneous and dexamethasone-induced catagen showing pigment incontinence, while cyclophosphamide-induced catagen retained dendritic melanocytes but increased ectopic melanin.

research Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools

135 citations , May 1994 in “Medical Entomology and Zoology”

This collection reviews various animal models for dermatological research, particularly focusing on genetic mutations in laboratory mice, and reports no original findings.

research Histochemistry of the Human Hair Follicle with Consideration of Anagen Phases I to VI

18 citations , June 1992 in “Acta Histochemica”

Human hair follicles have a unique cell distribution and differentiation pattern during growth.