Signature Selection Analysis Reveals Candidate Genes Associated With Production Traits in Iranian Sheep Breeds

The study analyzed the genetic data of 324 sheep from three Iranian breeds (Moghani, Afshari, and Gezel) and compared them with commercial breeds to identify genes associated with wool production and adaptation to harsh environments. Using Fst and nucleotide diversity statistics, the researchers identified several candidate genes, including KRTAP20-2, PTPN3, LHX2, COL17A1, CORIN, CPQ, PLCB4, FAM107B, PIK3C2B, and USP43. These genes are linked to traits such as wool fiber curvature, crimp traits, and heat stress adaptation. The findings suggest potential targets for breeding programs, though further research is needed to confirm phenotype-genotype relationships.