Expression Analysis of the Type I Keratin Protein Keratin 33A in Goat Coat Hair

July 2011 in “ Animal science journal ”

Yuta Seki, Michinari Yokohama, Kenta Wada, Masatoshi Fujita, Mai Kotani, Yoshio Nagura, Masako Kanno, Kou Nomura, Takashi Amano, Yoshiaki Kikkawa

keratin 33A keratin hair coat tissues immunohistochemistry cortex cashmere fibers structural protein hair coat cashmere

Studysummary The researchers reported that keratin 33A is a structural protein specific to goat cashmere hair, with increased winter expression in high-cashmere-producing breeds. Our plain-language summary of this paper — not a Tressless recommendation.

The study focused on the expression of the keratin 33A protein in goat coat hair, revealing that it is a major keratin highly expressed in winter coats. Western analysis showed that keratin 33A is specific to hair coat tissues and its expression increased in winter for high-producing Korean native breeds but not in low-producing Saanen breeds. Immunohistochemistry localized keratin 33A in the cortex of cashmere fibers, confirming its role as a structural protein in goat cashmere hair.

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