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    Glossary Epidermal Differentiation Complex

    cluster of genes crucial for skin barrier formation

    The Epidermal Differentiation Complex (EDC) is a cluster of genes located on chromosome 1 in humans that play a crucial role in the formation and maintenance of the skin barrier. These genes are responsible for producing proteins that help skin cells mature and form the outermost layer of the skin, which protects the body from environmental damage and prevents water loss.

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    1. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    2. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    3. Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis Frontiers in Bioscience-Landmark · 2022 · 12 citations
    4. Dynamics and Epigenetics of the Epidermal Differentiation Complex Epigenomes · 2024
    5. 177 The Striatin-Interacting Phosphatase And Kinases complex is important for skin epidermal differentiation and barrier formation 2022
    6. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation Toxicological sciences · 2011 · 86 citations
    7. Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. The Journal of Cell Biology · 1989 · 198 citations
    8. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    9. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    10. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
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