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    Glossary Epidermal Differentiation Complex

    cluster of genes crucial for skin barrier formation

    The Epidermal Differentiation Complex (EDC) is a cluster of genes located on chromosome 1 in humans that play a crucial role in the formation and maintenance of the skin barrier. These genes are responsible for producing proteins that help skin cells mature and form the outermost layer of the skin, which protects the body from environmental damage and prevents water loss.

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    1. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    2. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    3. Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis Frontiers in Bioscience-Landmark · 2022 · 12 citations
    4. Dynamics and Epigenetics of the Epidermal Differentiation Complex Epigenomes · 2024
    5. 177 The Striatin-Interacting Phosphatase And Kinases complex is important for skin epidermal differentiation and barrier formation 2022
    6. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation Toxicological sciences · 2011 · 86 citations
    7. Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. The Journal of Cell Biology · 1989 · 198 citations
    8. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    9. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    10. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    11. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    12. Eph/ephrin signaling in epidermal differentiation and disease Seminars in Cell & Developmental Biology · 2011 · 42 citations
    13. p63 regulates <i>Satb1</i> to control tissue-specific chromatin remodeling during development of the epidermis The Journal of Cell Biology · 2011 · 166 citations
    14. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium Mechanisms of Development · 2004 · 56 citations
    15. Single-cell transcriptomics defines keratinocyte differentiation in avian scutate scales Scientific reports · 2022 · 5 citations
    16. Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin Genes & Development · 2001 · 555 citations
    17. Author response: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures 2016 · 3 citations
    18. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation Frontiers in Cell and Developmental Biology · 2026
    19. Genome-wide association study of skin complex diseases Journal of Dermatological Science · 2012 · 25 citations
    20. 1337 Single cell transcriptome profiling of human interfollicular epidermis reveals robust heterogeneity and divergent differentiation lineages Journal of Investigative Dermatology · 2018
    21. Similar response patterns to topical minoxidil foam 5% in frontal and vertex scalp of men with androgenetic alopecia: a microarray analysis British Journal of Dermatology · 2014 · 19 citations
    22. Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures Animals · 2025
    23. Convergent evolution has led to the loss of claw proteins in snakes and worm lizards Genome Biology and Evolution · 2024
    24. 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification Journal of Investigative Dermatology · 2016
    25. Stem Cells behind the Barrier International journal of molecular sciences · 2013 · 22 citations
    26. Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease Stem cell biology and regenerative medicine · 2018
    27. MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters Nature communications · 2023 · 1 citations
    28. MOF-mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions By Controlling Gene Promoters bioRxiv (Cold Spring Harbor Laboratory) · 2022
    29. GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states PLOS Genetics · 2017 · 38 citations
    30. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations 2011 · 41 citations