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    Glossary Epidermal Differentiation Genes

    regulate skin cell maturation and barrier formation

    Epidermal Differentiation Genes are a group of genes that play a crucial role in the development and maturation of the outermost layer of the skin, known as the epidermis. These genes regulate the process by which skin cells (keratinocytes) mature, form protective barriers, and eventually shed, ensuring the skin remains healthy and functional.

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    1. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    2. 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation 2021
    3. Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2007 · 19 citations
    4. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation Toxicological sciences · 2011 · 86 citations
    5. Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2 Journal of Investigative Dermatology · 1999 · 49 citations
    6. 707 Chromatin remodeler Lymphoid-specific helicase (Lsh) is a critical determinant controlling postnatal epidermal growth, differentiation and response to injury Journal of Investigative Dermatology · 2016
    7. 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles 2021
    8. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    9. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    10. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
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