Second International Symposium: Epigenetic Regulation of Skin Regeneration and Aging

August 2017 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Vladimir A. Botchkarev

DNA methylation histone deacetylases Polycomb Group proteins noncoding RNAs cytokine mRNA translation keratinocyte differentiation exosome potential cellular senescence chromatin remodeling epigenetic mechanisms skin inflammation skin cancer

TLDR Epigenetic factors play a crucial role in skin health and disease.

The Second International Symposium on Epigenetic Regulation of Skin Regeneration and Aging, held in March 2016, gathered over 110 participants to discuss advancements in skin epigenetics. Key topics included DNA and histone modifications, signaling and epigenetic mechanisms, and chromatin architecture's impact on cell differentiation and cancer. Presentations highlighted the roles of DNA methylation, histone deacetylases, Polycomb Group proteins, and noncoding RNAs in skin development and disease. The symposium emphasized the complexity of epigenetic regulation in skin biology and its implications for understanding and treating skin diseases, with notable research on cytokine mRNA translation, keratinocyte differentiation, exosome potential, cellular senescence, mechanical forces on chromatin remodeling, and new epigenetic mechanisms in skin inflammation and cancer.

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