TLDR Epigenetic factors play a crucial role in skin health and disease.
The Second International Symposium on Epigenetic Regulation of Skin Regeneration and Aging, held in March 2016, gathered over 110 participants to discuss advancements in skin epigenetics. Key topics included DNA and histone modifications, signaling and epigenetic mechanisms, and chromatin architecture's impact on cell differentiation and cancer. Presentations highlighted the roles of DNA methylation, histone deacetylases, Polycomb Group proteins, and noncoding RNAs in skin development and disease. The symposium emphasized the complexity of epigenetic regulation in skin biology and its implications for understanding and treating skin diseases, with notable research on cytokine mRNA translation, keratinocyte differentiation, exosome potential, cellular senescence, mechanical forces on chromatin remodeling, and new epigenetic mechanisms in skin inflammation and cancer.
179 citations,
July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
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118 citations,
January 2016 in “Current Topics in Developmental Biology” The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.
321 citations,
March 2015 in “Nature” Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.
72 citations,
July 2012 in “Journal of Investigative Dermatology” Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.
56 citations,
February 2012 in “Cell Cycle” MicroRNAs are crucial for controlling skin development and healing by regulating genes.
129 citations,
July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
January 2018 in “Stem cell biology and regenerative medicine” The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
37 citations,
November 2017 in “Medical Sciences” Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.
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10 citations,
May 2019 in “Seminars in Cell & Developmental Biology” Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.
218 citations,
September 2012 in “Gastroenterology” Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.
