A Liposome-Based Formulation Containing Equol, Dihomo-γ-Linolenic Acid, and Propionyl-L-Carnitine to Prevent and Treat Hair Loss: A Prospective Investigation

    October 2018 in “ Dermatologic Therapy
    G Brotzu, Anna Maria Fadda, Matteo Manca, Thomas Manca, Francesca Marongiu, Manuela Campisi, Francesca Consolaro
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    TLDR The lotion with equol, dihomo-γ-linolenic acid, and propionyl-l-carnitine was effective in reducing hair loss in men and women.
    In 2018, a study was conducted on 60 participants (30 men and 30 women) with signs of androgenic alopecia, using the lotions TRINOV Lozione Anticaduta Uomo and TRINOV Lozione Anticaduta Donna. These lotions contained dihomo-γ-linolenic acid (DGLA), S-equol, and propionyl-l-carnitine, which were loaded into liposomes for effective transdermal delivery. DGLA improves microcirculation, S-equol inhibits the transformation of testosterone into dihydrotestosterone, and propionyl-l-carnitine stimulates energy production. After 6 months of daily topical applications, a significant increase in hair count was observed in women and a marginal increase in men. Additionally, a significant increase in anagen hair and a significant decrease in telogen hair were observed starting from 3 months in male and 1 month in female patients. The study concluded that these formulations were effective in attenuating androgenic alopecia-related hair loss in both men and women.
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