An Osteopontin-Derived Peptide Inhibits Human Hair Growth by Decreasing Fibroblast Growth Factor-7 Production in Outer Root Sheath Keratinocytes

September 2019 in “ British Journal of Dermatology ”

Majid Alam, Marta Bertolini, Jennifer Gherardini, Aviad Keren, L. Ponce, Jérémy Chéret, Jan Alenfall, Pontus Dunér, Astrid Nilsson, Amos Gilhar, Ralf Paus

osteopontin-derived peptide FOL-005 fibroblast growth factor-7 FGF7 catagen hair follicle stem cells hirsutism hypertrichosis outer root sheath keratinocytes

TLDR FOL-005 peptide can reduce human hair growth by lowering FGF7 levels.

The study investigated the effects of an osteopontin-derived peptide, FOL-005, on human hair growth, aiming to develop a safe and effective treatment for unwanted hair growth conditions like hirsutism and hypertrichosis. Conducted both ex vivo and in vivo, the research demonstrated that FOL-005 significantly promoted premature catagen development in human hair follicles without reducing the number of hair follicle stem cells or causing toxicity. The peptide decreased the expression of fibroblast growth factor-7 (FGF7), a hair growth promoter, and its effects were partially reversed by recombinant FGF7. The findings suggested that FOL-005 could be a promising novel inhibitor for human hair growth, warranting further clinical testing.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

27 / 27 results

research Effect of Laser Diode Light Irradiation on Growth Capability of Human Hair Follicle Dermal Papilla Cells

8 citations , July 2017

Laser diode light boosts hair follicle cell growth and certain gene expressions.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Endocrine Evaluation of Hirsutism

29 citations , February 2017 in “International Journal of Women's Dermatology”

Women with excessive male-pattern hair growth should get a full hormone check-up to find and treat any underlying issues, considering both medical and emotional aspects.

research Evaluation of Gene Expression Patterns in Micrografts Demonstrates Induction of Catagen-Like Processes During Storage

5 citations , January 2017 in “Dermatologic Surgery”

Storing hair follicle micrografts for longer times can cause them to enter a state similar to the natural hair shedding phase, which might impact hair transplant results.

research Hominis Placenta Facilitates Hair Regrowth by Upregulating Cellular Proliferation and Expression of Fibroblast Growth Factor-7

13 citations , July 2016 in “BMC Complementary and Alternative Medicine”

Hominis Placenta helps hair grow back by increasing cell growth and a specific growth factor.

research Androgen Excess: Investigations and Management

82 citations , May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

research The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo

17 citations , April 2016 in “Journal of Investigative Dermatology”

KB2115 (eprotirome) can safely extend the hair growth phase without damaging cells or changing hair color.

research Interventions for Hirsutism Excluding Laser and Photoepilation Therapy Alone: Abridged Cochrane Systematic Review Including GRADE Assessments

30 citations , February 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

Some medications can reduce excessive hair growth in women, but more research is needed to find the best treatment combinations.

research Role of Arachidonic Acid in Promoting Hair Growth

29 citations , January 2016 in “Annals of dermatology/Annals of Dermatology”

Arachidonic acid helps hair grow by increasing growth factors and improving follicle health.

research Bee Venom Promotes Hair Growth by Inhibiting 5α-Reductase Expression

15 citations , January 2016 in “Biological & Pharmaceutical Bulletin”

Bee venom helps hair grow and may work better than some common treatments.

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations , September 2015 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives

130 citations , August 2015 in “Experimental Dermatology”

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

research Congenital Generalized Hypertrichosis: The Skin as a Clue to Complex Malformation Syndromes

53 citations , August 2015 in “The Italian Journal of Pediatrics/Italian journal of pediatrics”

Excessive body hair can signal complex health issues.

research 5% Minoxidil: Treatment for Female Pattern Hair Loss

8 citations , March 2015 in “PubMed”

5% minoxidil foam effectively treats female hair loss.

research Hair Growth Promotion Activity and Its Mechanism of Polygonum Multiflorum

24 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

Polygonum multiflorum can promote hair growth when taken orally or applied topically.

research Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice

43 citations , July 2014 in “Experimental Dermatology”

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

research A New Humanized Mouse Model For Alopecia Areata

25 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

A new mouse model helps understand and find treatments for alopecia areata.

research Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation

28 citations , November 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

GMG-43AC may help reduce unwanted hair growth and treat certain hair loss conditions.

research How to Diagnose and Treat Women with Excessive Hair

17 citations , October 2012 in “Dermatologic clinics”

Treating excessive hair in women requires a holistic approach, including medical, aesthetic, and emotional support.

research The Hirsute Woman: Challenges in Evaluation and Management

22 citations , August 2011 in “Endocrine Practice”

Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.

research Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture

132 citations , September 2009 in “Experimental Dermatology”

A reliable system was developed to distinguish hair growth stages, aiding in identifying hair growth promoters or inhibitors.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Dissecting the Impact of Chemotherapy on the Human Hair Follicle

99 citations , September 2007 in “The American journal of pathology”

Chemotherapy damages hair follicles, causing hair loss and other cellular changes.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Osteopontin Gene Is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner

17 citations , December 2001 in “Journal of Investigative Dermatology”

The osteopontin gene is active in a specific part of rat hair follicles during a certain hair growth phase and might affect hair cycle and diseases.

research Osteopontin of Skin and Hair Follicle of Rat

1 citations , June 2000 in “PubMed”

Osteopontin may help hair follicle growth during the catagen phase.

research Topical Minoxidil for Hair Growth in Alopecia Areata and Androgenetica

24 citations , February 1987 in “Drugs”

Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.

Similar Research

5 / 188 results

research Osteopontin Regulatory Functions in the Hair Follicle Open a Therapeutic Approach for Hypertrichosis

November 2019 in “British Journal of Dermatology”

FOL-005 peptide may help treat excessive hair growth safely.

research FGF7-Dependent Inhibition of Human Hair Growth by an Osteopontin-Derived Peptide: A Novel Solution for Hirsutism and Hypertrichosis

April 2018 in “Journal of Investigative Dermatology”

A new peptide, FOL-005, may help treat excessive hair growth by reducing a hair growth promoter, FGF7.

research Identification of an Osteopontin-Derived Peptide That Binds Neuropilin-1 and Activates Vascular Cells

September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

FOL-026 peptide can help repair blood vessels and promote growth, offering potential treatment for vascular diseases.

research A Novel Microparticle-Based Formulation for Topical Delivery of FOL-005, a Small Peptide

1 citations , January 2022 in “Journal of Pharmaceutical Sciences”

The new skin cream with FOL-005 safely promotes hair growth and is stable and user-friendly.

research Proceedings of the Ninth World Congress for Hair Research 2015

January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.