An Osteopontin-Derived Peptide Inhibits Human Hair Growth by Decreasing Fibroblast Growth Factor-7 Production in Outer Root Sheath Keratinocytes

September 2019 in “ British Journal of Dermatology ”

Majid Alam, Marta Bertolini, Jennifer Gherardini, Aviad Keren, L. Ponce, Jérémy Chéret, Jan Alenfall, Pontus Dunér, Astrid Nilsson, Amos Gilhar, Ralf Paus

osteopontin-derived peptide FOL-005 fibroblast growth factor-7 FGF7 catagen hair follicle stem cells hirsutism hypertrichosis outer root sheath keratinocytes

TLDR FOL-005 peptide can reduce human hair growth by lowering FGF7 levels.

The study investigated the effects of an osteopontin-derived peptide, FOL-005, on human hair growth, aiming to develop a safe and effective treatment for unwanted hair growth conditions like hirsutism and hypertrichosis. Conducted both ex vivo and in vivo, the research demonstrated that FOL-005 significantly promoted premature catagen development in human hair follicles without reducing the number of hair follicle stem cells or causing toxicity. The peptide decreased the expression of fibroblast growth factor-7 (FGF7), a hair growth promoter, and its effects were partially reversed by recombinant FGF7. The findings suggested that FOL-005 could be a promising novel inhibitor for human hair growth, warranting further clinical testing.

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