Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms

January 2014 in “ International Journal of Medical Sciences ”

Weiming Qiu, Mingxing Lei, Jin Li, Ning Wang, Xiaohua Lian

TLDR Abnormal activation of hair follicle stem cells and Wnt/β-catenin signaling contributes to sebaceous neoplasms.

The study investigated the role of hair follicle stem cells (HFSCs) and Wnt/β-catenin signaling in the development of sebaceous neoplasms. Using DMBA and TPA treatments, researchers identified sebaceous neoplasms and analyzed them through staining techniques. They found that HFSCs, marked by SOX-9 and CD34, were present and active in the basal layer of sebaceous lobules within the neoplasms. Additionally, Wnt10b/β-catenin signaling was activated in these cells. The findings suggested that the abnormal activation of HFSCs and Wnt10b/β-catenin signaling played a role in the pathogenesis of sebaceous neoplasms.

View this study on medsci.org →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

77 citations , July 2012 in “Journal of Investigative Dermatology”

Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations , June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

research Differential Sensitivity of Epidermal Cell Subpopulations to Beta-Catenin-Induced Ectopic Hair Follicle Formation

43 citations , April 2010 in “Developmental Biology”

Sebaceous glands can form new hair follicles when activated, but hair follicle bulges cannot.

research CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice

141 citations , May 2007 in “Cancer Research”

research Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis

421 citations , September 2003 in “Development”

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

research Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors

297 citations , January 2002 in “Development”

Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.

research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

555 citations , July 2001 in “Genes & Development”

Tcf3 and Lef1 are key in deciding skin stem cell roles.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

Related Research

2 / 2 results

research Hair Disorders

October 2018 in “Springer eBooks”

The document concludes that various hair disorders have different treatments, including medication, surgery, and addressing underlying causes.

research Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland

30 citations , April 2018 in “Experimental Dermatology”

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.