Inhibition of CISD1 Attenuates Cisplatin-Induced Hearing Loss in Mice via the PI3K and MAPK Pathways

    May 2024 in “ Biochemical pharmacology ”
    Dong Wang, Yumeng Jiang, Qi Yao … Dongzhen Yu
    Studysummary This study found that targeting CISD1 with the compound NL-1 reduced mitochondrial dysfunction and reactive oxygen species accumulation, protecting against cisplatin-induced hearing loss in cell models and mice, without affecting cisplatin's cancer-fighting effectiveness.
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