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Glossary Cisplatin

chemotherapy drug that damages cancer cell DNA

Cisplatin, also known as CDDP, is a chemotherapy drug used to treat various types of cancer, including testicular, ovarian, bladder, and lung cancers. It works by binding to DNA in cancer cells, causing damage that prevents the cells from dividing and growing, ultimately leading to cell death. This drug is effective but can have significant side effects, including nephrotoxicity (kidney damage) and ototoxicity (hearing loss).

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Docetaxel, Cisplatin and 5-Fluorouracil in Patients with Locally Advanced Unresectable Head and Neck Cancer: A Phase I-II Feasibility Study

research Docetaxel, cisplatin and 5-fluorouracil in patients with locally advanced unresectable head and neck cancer: a phase I–II feasibility study

78 citations , March 2004 in “Annals of Oncology”

This study found that the combination of docetaxel, cisplatin, and 5-fluorouracil is active and feasible for treating squamous cell carcinoma of the head and neck, with dose level I recommended for further testing.

research Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism

52 citations , May 2011 in “APOPTOSIS”

In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.

Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

research Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

8 citations , June 2021 in “International Journal of Molecular Sciences”

In this study, UCMSC exosomes showed protective effects against cisplatin-induced hearing loss in mice by improving hearing and promoting cochlear tissue repair.

research Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation

2 citations , January 2023 in “Redox Report”

This study found that estradiol significantly reduces cisplatin-induced cochlear hair cell death in mice, likely by activating Nrf2 and phase II detoxification enzymes.

research 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway

1 citations , March 2024 in “Journal of Cellular and Molecular Medicine”

In this study, researchers found that 4-Octyl itaconate (4-OI) inhibited cisplatin-induced ferroptosis and protected auditory cells by activating the NRF2/HO-1 signaling pathway, suggesting a potential therapeutic approach for reducing hearing loss associated with cisplatin treatment.

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