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GlossaryCisplatin

chemotherapy drug that damages cancer cell DNA

Cisplatin, also known as CDDP, is a chemotherapy drug used to treat various types of cancer, including testicular, ovarian, bladder, and lung cancers. It works by binding to DNA in cancer cells, causing damage that prevents the cells from dividing and growing, ultimately leading to cell death. This drug is effective but can have significant side effects, including nephrotoxicity (kidney damage) and ototoxicity (hearing loss).

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Docetaxel, Cisplatin and 5-Fluorouracil in Patients with Locally Advanced Unresectable Head and Neck Cancer: A Phase I-II Feasibility Study

research Docetaxel, Cisplatin and 5-Fluorouracil in Patients with Locally Advanced Unresectable Head and Neck Cancer: A Phase I-II Feasibility Study

78 citations, March 2004 in “Annals of Oncology”

The treatment combining docetaxel, cisplatin, and 5-FU is feasible and effective for advanced head and neck cancer.

research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations, May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

research Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

8 citations, June 2021 in “International Journal of Molecular Sciences”

Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.

research Estradiol Protects Hair Cells From Cisplatin-Induced Ototoxicity Via Nrf2 Activation

2 citations, January 2023 in “Redox Report”

Estradiol may protect ear cells from hearing loss caused by a chemotherapy drug by activating a protective pathway.

research 4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway

1 citations, March 2024 in “Journal of Cellular and Molecular Medicine”

4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.

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community REGROWTH AFTER 12 YEARS! My doctor approves of self-prescribed gray market internet dutasteride!!

in Female 72 upvotes 1 week ago

A woman experienced hair regrowth after using self-prescribed finasteride and dutasteride from online sources, despite doctors' reluctance to prescribe these due to potential birth defects. Her dermatologist acknowledged the effectiveness of these treatments and advised her to continue using them while avoiding pregnancy.

community Was on a night out last night and someone brought up I was going bald.

in Chat 1 year ago

Someone who is 18 and has been balding since 15 starting treatments with finasteride and minoxidil to stop or reverse their hair loss, as well as discussing the dilemma of whether it's rude or helpful to point out another person's hair loss.