4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway

    March 2024 in “ Journal of Cellular and Molecular Medicine ”
    Li Zhang, Wei Song, Li H, Xiaolin Cui, Jingyu Ma, Rongrong Wang, Yan Xu, Ming Li, Xiaohui Bai, Dawei Wang, Hongna Sun, Zhiming Lu
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    TLDR 4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.
    The study investigated the potential of 4-octyl itaconate (4-OI), an NRF2 activator, in mitigating cisplatin-induced hearing loss. Cisplatin, an antitumor drug, can cause irreversible hearing loss. The research involved 24 mice and used both in vitro and in vivo experiments. The results showed that 4-OI significantly reduced the toxic effects of cisplatin on HEI-OC1 cells and cochlear hair cells, and reduced the production of reactive oxygen species and inflammatory factors. It was found that 4-OI could potentially regulate the ferroptosis process and inhibit cisplatin-induced ferroptosis, likely through the activation of the NRF2/HO-1 signalling pathway. The study concluded that 4-OI effectively mitigated cisplatin-induced hearing loss in mice and preserved cell viability, suggesting it as a promising drug for the prevention of cisplatin-associated hearing impairment.
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