4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway

    March 2024 in “ Journal of Cellular and Molecular Medicine ”
    Li Zhang, Wei Song, Li H, Xiaolin Cui, Jingyu Ma, Rongrong Wang, Yan Xu, Ming Li, Xiaohui Bai, Dawei Wang, Hongna Sun, Zhiming Lu
    Image of study
    TLDR 4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.
    The study investigated the potential of 4-octyl itaconate (4-OI), an NRF2 activator, in mitigating cisplatin-induced hearing loss. Cisplatin, an antitumor drug, can cause irreversible hearing loss. The research involved 24 mice and used both in vitro and in vivo experiments. The results showed that 4-OI significantly reduced the toxic effects of cisplatin on HEI-OC1 cells and cochlear hair cells, and reduced the production of reactive oxygen species and inflammatory factors. It was found that 4-OI could potentially regulate the ferroptosis process and inhibit cisplatin-induced ferroptosis, likely through the activation of the NRF2/HO-1 signalling pathway. The study concluded that 4-OI effectively mitigated cisplatin-induced hearing loss in mice and preserved cell viability, suggesting it as a promising drug for the prevention of cisplatin-associated hearing impairment.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community 4 months on Dut, Min and Nizoral

      in Progress Pictures  107 upvotes 3 days ago
      The user reported significant hair regrowth after 4 months using Dutasteride, oral and topical Minoxidil, Nizoral shampoo, and dermastamping. They experienced minor side effects but noted consistent progress and regrowth, especially at the hairline and temples.

      community 4 months on 2.5mg Dut + 5mg oral minox daily

      in Progress Pictures  118 upvotes 1 week ago
      The conversation is about a user's positive experience with hair regrowth using 2.5mg daily of Dutasteride and 5mg oral Minoxidil, noting significant progress without major side effects. The user experienced an initial hair shed with Dutasteride, which stopped after starting Minoxidil, and recommends consulting a doctor before adjusting dosages.

      community 4 1/2 months of Dut and Oral Min Update

      in Update  370 upvotes 1 week ago
      Significant hair regrowth was achieved after 4.5 months using 0.5 mg Dutasteride and 5 mg oral Minoxidil. Tips on obtaining prescriptions and discussions on effectiveness and side effects were also shared.

      community 4 Months Minoxidil 5% and 1mg Finasterid

      in Progress Pictures  153 upvotes 3 weeks ago
      A 20-year-old user shared progress on hair regrowth after using Minoxidil 5% and 1mg Finasteride for four months, noting improvements in hairline thickness, especially at the temples, with no side effects. The user also started using a derma roller recently and plans to update progress every few months.

    Similar Research

    5 / 1000+ results