Topical SCD-153, A 4-Methyl Itaconate Prodrug, For The Treatment Of Alopecia Areata

December 2022 in “ PNAS nexus ”

Jerry Tsai, Sadakatali S. Gori, Jesse Alt, Sandhya Tiwari, Jitesh Iyer, Rashmi Talwar, Denish Hinsu, Kailash Ahirwar, Swayam Mohanty, Chintan Khunt, Brijesh Sutariya, Kaushal Jani, Venkatesha Venkatasubbaiah, Ashok R. Patel, Jasmin Meghapara, K. Joshi, Rajanikanta Sahu, Ritu Vijay, Prashant B. Nigade, Ravi S. Talluri, Kadiyala V S N Murty, Kiritkumar Joshi, Vikram Ramanathan, Ang Li, Nasif Islam, Ivan Šnajdr, Pavel Majer, Rana Rais, Barbara S. Slusher, Luis A. Garza

SCD-153 4-methyl itaconate alopecia areata topical treatment inflammatory markers human epidermal keratinocytes hair growth itaconate analogues JAK inhibitor tofacitinib 4-MI JAK inhibitors

TLDR SCD-153 shows promise as an effective topical treatment for alopecia areata.

SCD-153, a prodrug of 4-methyl itaconate (4-MI), was developed to treat alopecia areata by enhancing skin and cell penetration. In C57BL/6 mice, topical SCD-153 converted to 4-MI upon skin penetration and showed low systemic absorption. It significantly reduced inflammatory markers in human epidermal keratinocytes and induced significant hair growth in mice, outperforming vehicle, less cell-permeable itaconate analogues, and the JAK inhibitor tofacitinib. These findings suggest that SCD-153 is a promising topical treatment for alopecia areata.

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