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GlossaryHEI-OC1 cells

immortalized mouse inner ear cells used for auditory research

HEI-OC1 cells are a type of immortalized cell line derived from the inner ear of mice, specifically used for research on hearing and auditory function. These cells are valuable in scientific studies because they can proliferate indefinitely and are used to investigate the mechanisms of hearing loss, drug ototoxicity, and potential treatments for auditory disorders.

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Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

research Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

5 citations, November 2022 in “Molecular Neurobiology”

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

research Deferoxamine Protects Cochlear Hair Cells Against Tert-Butyl Hydroperoxide-Induced Ototoxicity

March 2024 in “Biochimica et biophysica acta. Molecular basis of disease”

Deferoxamine may help protect inner ear cells from damage caused by oxidative stress.

research Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway

5 citations, November 2021 in “Frontiers in Cell and Developmental Biology”

Caffeine can damage hearing cells and affect hearing recovery after ear trauma.

Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

research Melatonin Protects Cochlear Hair Cells from Nicotine-Induced Injury Through Inhibiting Apoptosis, Inflammation, Oxidative Stress, and Endoplasmic Reticulum Stress

5 citations, July 2021 in “Basic & Clinical Pharmacology & Toxicology”

Melatonin may protect ear cells from damage caused by nicotine.

research 4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway

1 citations, March 2024 in “Journal of Cellular and Molecular Medicine”

4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.

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