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    Glossary HEI-OC1 cells

    immortalized mouse inner ear cells used for auditory research

    HEI-OC1 cells are a type of immortalized cell line derived from the inner ear of mice, specifically used for research on hearing and auditory function. These cells are valuable in scientific studies because they can proliferate indefinitely and are used to investigate the mechanisms of hearing loss, drug ototoxicity, and potential treatments for auditory disorders.

    Research 10 of 93

    1. Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway Molecular Neurobiology · 2022 · 5 citations
    2. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity Biochimica et biophysica acta. Molecular basis of disease · 2024
    3. Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    4. 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway Journal of Cellular and Molecular Medicine · 2024 · 1 citations
    5. Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways Biochemical pharmacology · 2024
    6. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    7. CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress Biomedicine & Pharmacotherapy · 2023 · 4 citations
    8. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    9. Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells PLoS ONE · 2011 · 39 citations
    10. Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling Biocell · 2023
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