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    Glossary HEI-OC1 cells

    immortalized mouse inner ear cells used for auditory research

    HEI-OC1 cells are a type of immortalized cell line derived from the inner ear of mice, specifically used for research on hearing and auditory function. These cells are valuable in scientific studies because they can proliferate indefinitely and are used to investigate the mechanisms of hearing loss, drug ototoxicity, and potential treatments for auditory disorders.

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    Research 30 of 92

    1. Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway Molecular Neurobiology · 2022 · 5 citations
    2. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity Biochimica et biophysica acta. Molecular basis of disease · 2024
    3. Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway Frontiers in Cell and Developmental Biology · 2021 · 5 citations
    4. 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway Journal of Cellular and Molecular Medicine · 2024 · 1 citations
    5. Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways Biochemical pharmacology · 2024
    6. Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress Basic & Clinical Pharmacology & Toxicology · 2021 · 5 citations
    7. CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress Biomedicine & Pharmacotherapy · 2023 · 4 citations
    8. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    9. Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells PLoS ONE · 2011 · 39 citations
    10. Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling Biocell · 2023
    11. Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation Redox Report · 2023 · 2 citations
    12. MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation Biological Research · 2024
    13. XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss Advanced Science · 2026
    14. The Role of Nrf2 in Hearing Loss Frontiers in Pharmacology · 2021 · 17 citations
    15. Methods and Challenges in Purifying Drug‐Loaded Extracellular Vesicles Journal of Extracellular Vesicles · 2025 · 15 citations
    16. Associations of dietary indices with risk of all-cause and cardiovascular mortality in hypertensive adults Annals of Medicine · 2025 · 3 citations
    17. Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts International Journal of Molecular Sciences · 2018 · 68 citations
    18. Systemic Comorbidities in Korean Patients with Rosacea: Results from a Multi-Institutional Case-Control Study Journal of Clinical Medicine · 2020 · 17 citations
    19. Effects of topical application of EGCG on testosterone-induced hair loss in a mouse model Experimental Dermatology · 2011 · 14 citations
    20. Traumatic panniculitis with localized hypertrichosis: Two new cases and considerations The Journal of Dermatology · 2012 · 5 citations
    21. Associations Between Skin Microbiome and Metabolome in the Pathogenesis of Atopic Dermatitis Patients With Scalp Involvement Allergy Asthma and Immunology Research · 2024 · 3 citations
    22. Overview of Short Peptides for Hair Loss Biomedicines · 2026
    23. Perceptions and Experiences of Scalp Micropigmentation Among Dermatology Outpatients With Hair Loss: A Survey-Based Study Annals of Dermatology · 2025
    24. Metformin: A Potential Treatment for Acne, Hidradenitis Suppurativa and Rosacea Acta dermato-venereologica · 2023
    25. Issue Information Dermatologic Therapy · 2020
    26. Androgen Affects the Inhibitory Avoidance Memory by Primarily Acting on Androgen Receptor in the Brain in Adolescent Male Rats Brain Sciences · 2021 · 13 citations
    27. Enhancement of therapeutic potential of mesenchymal stem cell by IGF-1 delivery in PLGA microspheres for tissue regeneration Regenerative Therapy · 2024 · 8 citations
    28. Global trends in platelet-rich plasma research: A bibliometric review with hotspot visualization Medicine · 2026
    29. Hair regeneration using microneedle-assisted human basic fibroblast growth factor Journal of analytical & pharmaceutical research · 2023
    30. Overview and Future of Hemo-Components and Natural Guided Regeneration Open access journal of surgery · 2017