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    Glossary Cisplatin

    chemotherapy drug that damages cancer cell DNA

    Cisplatin, also known as CDDP, is a chemotherapy drug used to treat various types of cancer, including testicular, ovarian, bladder, and lung cancers. It works by binding to DNA in cancer cells, causing damage that prevents the cells from dividing and growing, ultimately leading to cell death. This drug is effective but can have significant side effects, including nephrotoxicity (kidney damage) and ototoxicity (hearing loss).

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    Research 30 of 661

    1. Docetaxel, cisplatin and 5-fluorouracil in patients with locally advanced unresectable head and neck cancer: a phase I–II feasibility study Annals of Oncology · 2004 · 78 citations
    2. Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism APOPTOSIS · 2011 · 52 citations
    3. Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice International Journal of Molecular Sciences · 2021 · 8 citations
    4. Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation Redox Report · 2023 · 2 citations
    5. 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway Journal of Cellular and Molecular Medicine · 2024 · 1 citations
    6. Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways Biochemical pharmacology · 2024
    7. Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling Biocell · 2023
    8. Acute severe hypokalemia caused by treatment of tongue squamous cell carcinoma with docetaxel and cisplatin: A case report World Journal of Clinical Oncology · 2024
    9. Docosahexaenoic acid-acylated astaxanthin esters alleviate cisplatin- induced acute kidney injury by modulating the ferroptosis-related GPX4/xCT signaling pathway and reducing oxidative stress Food Science and Human Wellness · 2026
    10. Effectiveness and Safety Profile of Cisplatin Versus Nab-Paclitaxel Concomitant Chemoradiotherapy in Postoperative Early-Stage Cancer of Cervix Biological and Clinical Sciences Research Journal · 2025
    11. Clinical Value Analysis of Pemetrexed Combined with Cisplatin in the Treatment of Non-Small Cell Lung Cancer Deleted Journal · 2023
    12. ODAC Votes No on IntraDose Injectible Cisplatin/Epinephrine Gel for Head and Neck Cancer Oncology Times · 2001
    13. The Efficacy and Safety of Anlotinib Plus Etoposide with Cisplatin/Carboplatin in the First-Line Treatment of Lung Cancer: A Phase II Clinical Study Journal of Cancer · 2024 · 5 citations
    14. [Efficacy and toxicity of pemetrexed or gemcitabine combined with cisplatin in the treatment of patients with advanced non-small cell lung cancer]. DOAJ (DOAJ: Directory of Open Access Journals) · 2012 · 3 citations
    15. Clinical efficacy and safety of Kanglaite injection, adjuvant cemcitabine and cisplatin chemotherapy for advanced non-small-cell lung cancer: A systematic review and meta-analysis Tropical Journal of Pharmaceutical Research · 2021 · 1 citations
    16. Non-thermal Acoustic Enhancement of Chemotherapeutic Effects of Cisplatin on Xenografted Cervical Cancer in Mice Anticancer Research · 2023
    17. Use of chemotherapy during human pregnancy Lancet Oncology · 2004 · 724 citations
    18. Molecular basis of hair cell loss 2015 · 66 citations
    19. Hair cell toxicology: With the help of a little fish Frontiers in cell and developmental biology · 2022 · 4 citations
    20. Absence of chemotherapy-induced alopecia with paclitaxel in a case of hypothyroidism: case report Annals of Oncology · 2003 · 3 citations
    21. Perspective Chapter: Appraisal of Paclitaxel (Taxol) Pros and Cons in the Management of Cancer – Prospects in Drug Repurposing IntechOpen eBooks · 2023 · 1 citations
    22. Why Do Not All Chemotherapy Patients Lose Their Hair? Answering an Intriguing Question Skin appendage disorders · 2021 · 1 citations
    23. Paclitaxel/Platinum combination regimen and alopecia 2012 · 1 citations
    24. ASSESSMENT OF SOCIODEMOGRAPHIC CHARACTERISTICS AND COMPARATIVE ANALYSIS OF ADVERSE DRUG REACTIONS AMONG OROPHARYNGEAL CANCER PATIENTS RECEIVING DIFFERENT CHEMOTHERAPEUTIC REGIMENS IN KARACHI, SINDH, PAKISTAN Genetics and Molecular Research · 2026
    25. Inositol hexaphosphate alleviates ototoxicity and age‐related hearing loss by preserving cochlear hair cells in mice British Journal of Pharmacology · 2025
    26. Alopecia como efeito colateral dos tratamentos em uso para o Cancro do Colo do Útero: possíveis terapêuticas preventivas Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · 2025
    27. Safety concerns of paternal drug exposure on fertility, pregnancy and offspring: An analysis based on the FDA adverse event reporting system Andrology · 2024
    28. MON-323 Metastatic Adrenocortical Carcinoma Presenting with Mixed Cushing's and Virilization Syndrome along with Bilateral Pulmonary Emboli Journal of the Endocrine Society · 2019
    29. AB032. Development of new treatment modality for male infertility by using phytopharmaceuticals Translational andrology and urology · 2018
    30. A prospective observational study on drug safety monitoring and Pharmacoeconomics in patients with locally advanced unresectable NSCLC in a tertiary care hospital International journal of basic and clinical pharmacology · 2018