Development of New Treatment Modality for Male Infertility Using Phytopharmaceuticals

September 2018 in “ Translational andrology and urology ”

Jong Kwan Park

finasteride reactive oxygen species endoplasmic reticulum stress varicocele cisplatin adriamycin Morinda officinalis Allium cepa Cuscuta chinensis ROS ER stress

TLDR MOTILIPERM may help treat male infertility by reducing stress in cells.

The study investigated the role of reactive oxygen species (ROS)-based endoplasmic reticulum (ER) stress in male infertility using a rat model of varicocele (VC) and treatments with cisplatin (CIS), adriamycin, or finasteride (FINA). The researchers evaluated the therapeutic efficacy of MOTILIPERM, a mixture of extracts from three medicinal herbs, in these models. Results showed that MOTILIPERM significantly increased left testis weight, testosterone levels, sperm motility, count, and spermatogenic cell density in VC-induced and drug-administered groups. Additionally, MOTILIPERM decreased malondialdehyde (MDA) and ROS/reactive nitrogen species (RNS) levels while increasing the GSH/GSSG ratio. The study concluded that ROS-related ER stress played a major role in male infertility induced by VC, FINA, CIS, or adriamycin, and that MOTILIPERM could be a useful therapeutic supplement or herbal medication for treating such infertility.

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