Paclitaxel and Platinum Combination Regimen and Alopecia

    January 2012 in “ Türk jinekoloji ve obstetrik derneði dergisi/Türk Jinekoloji ve Obstetrik Derneği dergisi ”
    Nejat Özgül, Özlem Erten, Soner Düzgüner, Taner Turan, İskender Kög, Nurettin Boran, İlknur Balta, Mehmet Köse
    TLDR Most patients experienced significant but reversible hair loss during treatment.
    The study retrospectively evaluated alopecia in 470 patients treated with a paclitaxel and platinum combination for various gynecological cancers from 1993 to 2006. Patients received 6 cycles of chemotherapy with either paclitaxel and carboplatin or paclitaxel and cisplatin. Grade 3 alopecia was observed in 91.7% of patients, with no cases of grade 4 alopecia. The severity and frequency of alopecia were similar between the two chemotherapy combinations. Alopecia became more pronounced with additional chemotherapy cycles but was reversible after treatment concluded.
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