Appraisal of Paclitaxel Pros and Cons in Cancer Management and Drug Repurposing Prospects

    January 2023 in “ IntechOpen eBooks ”
    John Oluwafemi Teibo, Chioma Ejiro Irozuru, Titilade Kehinde Ayandeyi Teibo, Olabode Omotoso, Ahmad O. Babalghith, Gaber El‐Saber Batiha
    TLDR Paclitaxel is an effective cancer drug with side effects and potential new uses beyond cancer.
    Paclitaxel (Taxol) is a potent anticancer drug effective against various cancers, including breast and ovarian cancer, by obstructing mitotic spindle formation and arresting the cell cycle at the G2/M phase. Despite its efficacy, it has notable side effects such as hair loss, numbness, and bone marrow suppression, and faces resistance mechanisms like P-glycoprotein efflux pumps. Combining paclitaxel with cisplatin improves survival rates in breast cancer patients. Recent studies suggest its potential in treating non-cancer diseases like COVID-19 and fibrosis. Future advancements may enhance its biosynthesis, reduce chemo-resistance, and improve targeted delivery, potentially expanding its therapeutic uses.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Hair Loss Results After 8 Months of Dutasteride

      in Progress Pictures  232 upvotes 2 weeks ago
      The user experienced increased hair density after 8 months of using dutasteride and 6 months of oral minoxidil. Some users joked about side effects, while others discussed the effectiveness of various treatments like finasteride and rosemary oil.

      community Hair Loss Due To Chlorine and Hard Metals In Water?

      in Research/Science  1 upvotes 1 month ago
      Hair loss possibly caused by chlorine and heavy metals in water was addressed by using a shower filter, ketoconazole shampoo, and PRP sessions, which stopped the hair loss but did not lead to regrowth. Other users suggested similar experiences and solutions, emphasizing the importance of a good water filter and patience for potential regrowth.

      community Hair Loss Treatments and Hair Transplant

      in Progress Pictures  4 upvotes 1 month ago
      The user is experiencing hair loss and is using oral finasteride, considering adding RU58841 and microneedling, and planning a hair transplant. They are seeking advice on whether to wait for treatment results or proceed with the transplant.

      community Hair loss steps, guide to beginners or anyone experiencing hair loss

      in Treatment  1 upvotes 1 month ago
      The conversation discusses a hair loss treatment regimen involving finasteride, dutasteride, spironolactone, bicalutamide, oral estradiol, microneedling, and minoxidil. The regimen aims to reduce androgenic alopecia by blocking DHT and androgens, with a caution about potential feminizing effects.

      community Hair loss 30F - thoughts on red light therapy vs min/fin?

      in Female  6 upvotes 1 month ago
      The conversation discusses hair loss treatments for a 30-year-old female, comparing red light therapy with minoxidil and finasteride. Concerns about hormonal impact and potential pregnancy are raised, with suggestions to consider spironolactone and microneedling, while emphasizing the importance of consulting a dermatologist.

    Similar Research

    5 / 1000+ results