TLDR Paclitaxel is an effective cancer drug with side effects and potential new uses beyond cancer.
Paclitaxel (Taxol) is a potent anticancer drug effective against various cancers, including breast and ovarian cancer, by obstructing mitotic spindle formation and arresting the cell cycle at the G2/M phase. Despite its efficacy, it has notable side effects such as hair loss, numbness, and bone marrow suppression, and faces resistance mechanisms like P-glycoprotein efflux pumps. Combining paclitaxel with cisplatin improves survival rates in breast cancer patients. Recent studies suggest its potential in treating non-cancer diseases like COVID-19 and fibrosis. Future advancements may enhance its biosynthesis, reduce chemo-resistance, and improve targeted delivery, potentially expanding its therapeutic uses.
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67 citations,
May 2018 in “Journal of Ginseng Research” Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.
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February 2020 in “Clinica chimica acta” Nano-sized plant-based chemicals could improve cervical cancer treatment by being more effective and causing fewer side effects than current methods.
3 citations,
June 2023 in “Molecules/Molecules online/Molecules annual” Cepharanthine has many medicinal uses but needs improvement for better effectiveness.
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18 citations,
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