Pharmacological Activity Of Cepharanthine

    June 2023 in “ Molecules/Molecules online/Molecules annual ”
    Ke Liu, Bixia Hong, Shuqi Wang … Yigang Tong
    Studysummary The researchers reviewed cepharanthine, a long-used bisbenzylisoquinoline alkaloid, for its antiviral properties, including significant inhibition of SARS-CoV-2. They discussed cepharanthine's other pharmacological actions, highlighted plasma membrane fluidity as a key antiviral mechanism, and examined its safety, bioavailability, and potential for new clinical applications.
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    Research cited in this study 17

    1. Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus International Journal of Molecular Sciences · 2022
    2. Lung-Targeted Delivery of Cepharanthine by an Erythrocyte-Anchoring Strategy for the Treatment of Acute Lung Injury Pharmaceutics · 2022
    3. Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo Viruses · 2022
    4. Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection Molecules · 2022
    5. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021
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