Pharmacological Activity Of Cepharanthine

Cepharanthine, a natural compound from the plant Stephania Cephalantha Hayata, has a variety of medicinal properties. It has demonstrated antitumor, anti-inflammatory, and antiviral activities, including against SARS-CoV-2. It works by stabilizing plasma membrane fluidity and blocking virus-cell interactions. Cepharanthine also has potential in treating autoimmune diseases, bone resorption, hair loss, and snake bites. It promotes hair cell proliferation and differentiation, especially when used with minoxidil. Despite its potential, cepharanthine has poor solubility and low bioavailability, which can affect its efficacy. However, no serious side effects have been reported in its current clinical use. Future research should focus on optimizing the administration mode and dosage form of cepharanthine to enhance its bioavailability.