Pharmacological Activity Of Cepharanthine

June 2023 in “ Molecules/Molecules online/Molecules annual ”

Ke Liu, Bixia Hong, Shuqi Wang, Fuxing Lou, Yecheng You, Ruolan Hu, Amna Shafqat, Huahao Fan, Yigang Tong

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From the encyclopedia

An essential vasodilator with some anti-androgenic effects

Studysummary The researchers reviewed cepharanthine, a long-used bisbenzylisoquinoline alkaloid, for its antiviral properties, including significant inhibition of SARS-CoV-2. They discussed cepharanthine's other pharmacological actions, highlighted plasma membrane fluidity as a key antiviral mechanism, and examined its safety, bioavailability, and potential for new clinical applications.

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research Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus

13 citations , September 2022 in “International Journal of Molecular Sciences”

This study identifies five compounds, including gemcitabine and methylene blue, that inhibit SADS-CoV and suggests their potential for developing antiviral drugs against future outbreaks.

research Lung-Targeted Delivery of Cepharanthine by an Erythrocyte-Anchoring Strategy for the Treatment of Acute Lung Injury

8 citations , August 2022 in “Pharmaceutics”

This study found that erythrocyte-anchored CPA-encapsulated nanoparticles improved the delivery and accumulation of Cepharanthine in the lungs, enhancing its effectiveness in treating acute lung injury by reducing inflammatory responses.

research Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo

34 citations , June 2022 in “Viruses”

This study found that the natural alkaloid cepharanthine effectively inhibited porcine epidemic diarrhea virus infection in newborn piglets.

research Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

14 citations , April 2022 in “Molecules”

This study found that pulmonary delivery of cepharanthine significantly improved bioavailability and may provide protective effects against pulmonary fibrosis related to COVID-19 infection in a rat model.

research Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways

30 citations , December 2021 in “Frontiers in Microbiology”

In this study, researchers found that cepharanthine significantly inhibited HSV-1 replication in vitro by interfering with specific signaling pathways, arresting the cell cycle, and inducing apoptosis in infected cells, highlighting its potential as an antiviral agent.

research Evaluating Cepharanthine Analogues as Natural Drugs Against SARS-CoV-2

29 citations , November 2021 in “FEBS Open Bio”

In this study, molecular docking simulations and cell-based assays suggested that certain analogues of cepharanthine might possess anti-SARS-CoV-2 activity.

Comparison of Viral RNA–Host Protein Interactomes Across Pathogenic RNA Viruses Informs Rapid Antiviral Drug Discovery for SARS-CoV-2

research Comparison of Viral RNA–Host Protein Interactomes Across Pathogenic RNA Viruses Informs Rapid Antiviral Drug Discovery for SARS-CoV-2

100 citations , November 2021 in “Cell Research”

This study found that SARS-CoV-2 hijacks the host factor IGF2BP1 to stabilize its RNA and enhance translation, and identified Cepharanthine and Trifluoperazine as potential treatments against the virus.

research Preparation and Evaluation of Self-Emulsifying Drug Delivery System of Cepharanthine

23 citations , October 2021 in “AAPS PharmSciTech”

research Structural Insights Into SARS-CoV-2 Spike Protein and Its Natural Mutants Found in Mexican Population

44 citations , February 2021 in “Scientific Reports”

This study found that specific mutations in the spike protein of SARS-CoV-2 may significantly alter its structure and affect how it binds to certain inhibitors, but experimental studies are needed to confirm potential clinical implications.

research Cepharanthine-Loaded Nanoparticles Coated With Macrophage Membranes for Lung Inflammation Therapy

45 citations , January 2021 in “Drug Delivery”

In this study, researchers developed a biomimetic anti-inflammatory nanosystem (MM-CEP/NLCs) that significantly reduced the severity of acute lung injury in vivo by targeting and accumulating in lung inflammation sites, showcasing its potential for treating inflammation.

research Cepharanthine Induces Proliferation of Human Dermal Papilla Cells and Stimulates Vascular Endothelial Growth Factor Expression Through Increased Intracellular Calcium Mobilization and Hypoxia-Inducible Factor Activation

7 citations , December 2020 in “Clinical and Experimental Dermatology”

This study found that cepharanthine and its structural analogues may stimulate hair growth by promoting the proliferation of human dermal papilla cells and increasing VEGF expression in vitro.

research Cepharanthine: A Review of the Antiviral Potential of a Japanese-Approved Alopecia Drug in COVID-19

70 citations , July 2020 in “Pharmacological Reports”

This review discusses the antiviral potential of cepharanthine against SARS-CoV-2, noting its effectiveness in preclinical models but presenting no new clinical results.

research Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications

125 citations , May 2019 in “Phytomedicine”

This review discusses the historical development, mechanisms of action, and potential new clinical applications of the drug cepharanthine, highlighting its multi-faceted pharmacological properties; it reports no new clinical results.

Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

research Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

13 citations , October 2013 in “The Journal of Dermatology”

This study found that topical cepharanthine increased IGF-I production in human dermal papilla cells, suggesting it may stimulate hair growth and be a promising treatment option for androgenetic alopecia.

research Seventeen Cases of Alopecia Areata: Combination of SADBE Topical Immunotherapy with Other Therapies

36 citations , October 2002 in “The Journal of Dermatology”

This study suggests that combining topical squaric acid dibutylester with other therapies may improve hair regrowth in patients with alopecia areata unresponsive to topical therapy alone.

research Bisbenzylisoquinoline Alkaloids from Stephania Cepharantha and Their Effects on Proliferation of Cultured Cells from the Murine Hair Apparatus

26 citations , October 1997 in “Planta Medica”

This study found that bisbenzylisoquinoline alkaloids from Stephania cepharantha Hayata stimulated growth in cultured murine hair cells but not in keratinocytes or fibroblasts.

research Effects of Cepharanthine and Minoxidil on Proliferation, Differentiation, and Keratinization of Cultured Cells from the Murine Hair Apparatus

23 citations , September 1992 in “Archives of Dermatological Research”

Cepharanthine and minoxidil promote cell growth and delay hair cell maturation.