Safety Concerns of Paternal Drug Exposure on Fertility, Pregnancy, and Offspring: An Analysis Based on the FDA Adverse Event Reporting System

    October 2024 in “ Andrology ”
    Yanbin Zeng, Wanlong Lin, Wei Zhuang
    Image of study
    TLDR Paternal drug exposure can harm fertility, pregnancy outcomes, and offspring health, with specific drugs linked to various reproductive issues.
    The study analyzes data from the FDA Adverse Event Reporting System to assess the impact of paternal drug exposure on fertility, pregnancy, and offspring health. It examines 16,180,533 reports, with 3,210 related to paternal exposure, revealing significant risks associated with certain drugs. Notably, biologics for inflammatory diseases, diazepam, and finasteride are linked to adverse reproductive outcomes, while immunosuppressive and antiepileptic drugs show strong signals for congenital anomalies. Chemotherapy drugs may be associated with genetic risks. The study underscores the need for further research and preconception counseling to address these risks, despite limitations such as reporting biases and the absence of maternal data.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Finasteride and fertility. Personal report.

      in Finasteride/Dutasteride  829 upvotes 6 months ago
      Finasteride can affect sperm quality, but fertility usually returns after stopping it, as shown by a user who conceived four months after discontinuation. Some users successfully conceive while on finasteride, though some prefer to pause its use to minimize risks.
      27M on Finasteride/Minoxidil 8-9 Months, Considering Dutasteride for Hair Loss

      community 27M on Finasteride/Minoxidil 8-9 Months, Considering Dutasteride for Hair Loss

      in Finasteride  71 upvotes 4 days ago
      The user has been using finasteride and minoxidil for 8-9 months without significant improvement in hair loss and is considering switching to dutasteride and topical minoxidil. Another user suggests that dutasteride might be more effective due to its potency and advises patience as hair regrowth can take up to a year.

      community 18M: Side Effects After 3 Months on Topical Finasteride

      in Finasteride  102 upvotes 6 days ago
      An 18-year-old using topical finasteride for hair loss is experiencing side effects like delayed ejaculation and lower sex drive after three months. They are considering whether to continue with the treatment or adjust it, possibly switching back to minoxidil.

      community When should I start using Finasteride (21M)

      in Finasteride  68 upvotes 1 week ago
      A 21-year-old male recently had a hair transplant and is considering starting finasteride to prevent further hair loss. Finasteride can be started immediately to maintain existing hair, with potential side effects like decreased libido, and results may take several months.

    Related Research

    1 / 1 results