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GlossaryEtoposide

chemotherapy drug that inhibits DNA replication in cancer cells

Etoposide, also known as VP-16, is a chemotherapy drug used to treat various types of cancer, including lung cancer, testicular cancer, and certain types of lymphomas. It works by inhibiting the enzyme topoisomerase II, which is essential for DNA replication and cell division, thereby preventing cancer cells from multiplying.

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research VP-16-213 (Etoposide): The Mandrake Root from Issyk-Kul

79 citations, January 1982 in “The American Journal of Medicine”

Etoposide is effective in treating several cancers, especially small cell lung cancer, with acceptable side effects.

research PH Sensitive Nano Layered Double Hydroxides Reduce the Hematotoxicity and Enhance the Anticancer Efficacy of Etoposide on Non-Small Cell Lung Cancer

65 citations, October 2015 in “Acta Biomaterialia”

The nano-carrier makes etoposide safer and more effective against lung cancer.

$Mitoxantrone, Etoposide, and Prednisolone: A Novel Combination in the Treatment of Relapsed and Refractory Lymphoma$

research Mitoxantrone, Etoposide, and Prednisolone: A Novel Combination in the Treatment of Relapsed and Refractory Lymphoma

2 citations, January 1990 in “Leukemia & Lymphoma”

The combination of mitoxantrone, etoposide, and prednisolone is effective for treating relapsed lymphoma with manageable side effects.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations, January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

research Vitamin D3 and Chemotherapy-Induced Alopecia

11 citations, June 1996 in “Nutrition”

Vitamin D3 may prevent hair loss from chemotherapy, but side effects and cancer cell protection are concerns.

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