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GlossaryEtoposide

chemotherapy drug that inhibits DNA replication in cancer cells

Etoposide, also known as VP-16, is a chemotherapy drug used to treat various types of cancer, including lung cancer, testicular cancer, and certain types of lymphomas. It works by inhibiting the enzyme topoisomerase II, which is essential for DNA replication and cell division, thereby preventing cancer cells from multiplying.

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research TICE Salvage Chemotherapy Treats Germ-Cell Tumors Effectively

April 2007 in “Nature Clinical Practice Urology”

TICE salvage chemotherapy is effective for treating germ-cell tumors with poor prognosis.

research Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors

153 citations, January 2001 in “Science”

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

Safety Concerns of Paternal Drug Exposure on Fertility, Pregnancy, and Offspring: An Analysis Based on the FDA Adverse Event Reporting System

research Safety Concerns of Paternal Drug Exposure on Fertility, Pregnancy, and Offspring: An Analysis Based on the FDA Adverse Event Reporting System

October 2024 in “Andrology”

Paternal drug exposure can harm fertility, pregnancy outcomes, and offspring health, with specific drugs linked to various reproductive issues.

research Effect of Cellular Blood Components on Chemotherapy-Induced Alopecia

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mononuclear cells may protect against certain chemotherapy-induced hair loss.

research Resolution of Plantar Hyperkeratosis of Pachyonychia Congenita During Chemotherapy for Ewing Sarcoma

2 citations, August 2013 in “British Journal of Dermatology”

Chemotherapy improved a girl's painful foot condition linked to pachyonychia congenita.

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