Multidimensional Assessment of Adverse Events of Finasteride: A Real-World Pharmacovigilance Analysis Based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024

    August 2024 in “ medRxiv (Cold Spring Harbor Laboratory) ”
    Xiaoling Zhong, Yihan Yang, Sheng Wei, Yuchen LIU

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that finasteride use is associated with both known and new adverse events, which vary by gender and age, as well as some events not previously listed in the drug insert.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 55

    1. Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies Journal of clinical medicine · 2024
    2. An Unusual Case of Thalamic Stroke in a Young Adult With Patent Foramen Ovale and Finasteride Use Curēus · 2024
    3. Association of 5α-Reductase Inhibitors With Depression and Suicide: A Mini Systematic Review and Meta-Analysis European urology focus · 2024
    4. Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats Journal of psychiatric research · 2024
    5. Sexual Dysfunction With 5-Alpha-Reductase Inhibitor Therapy for Androgenetic Alopecia: A Global Propensity Score Matched Retrospective Cohort Study Journal of the American Academy of Dermatology · 2024
    6. Updated Review of Treatment of Androgenetic Alopecia Facial plastic surgery clinics of North America · 2024
    7. Analysis of Finasteride Treatment and Its Withdrawal in Rat Hypothalamus and Hippocampus at Whole-Transcriptome Level Journal of Endocrinological Investigation · 2024
    8. Factors Associated With Early-Onset Androgenetic Alopecia: A Scoping Review PLOS ONE · 2024
    9. Enhancing Quality of Life and Sexual Functioning in Female Androgenetic Alopecia: Therapeutic Potential of Hair Follicle-Derived Stem Cells Healthcare · 2024
    10. Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Clinically Similar Conditions Frontiers in Neuroendocrinology · 2023
    11. Maculopapular Drug Eruption Caused by Finasteride: A Case Report Clinical, Cosmetic and Investigational Dermatology · 2023
    12. The Post-Finasteride Syndrome: Possible Etiological Mechanisms and Symptoms International journal of impotence research · 2023
    13. Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta-Analysis Psychology, Health & Medicine · 2023
    14. Beliefs and Counseling Practices Among Dermatologists Regarding Sexual and Other Adverse Effects of Finasteride International journal of impotence research · 2023
    15. Androgenetic Alopecia: An Update JAAD International · 2023
    16. Androgenetic Alopecia: Traditional Cardiovascular Risk Factors, Metabolic Syndrome, and Component Traits Among Nigerian Adults Nigerian Journal of Clinical Practice · 2023
    17. Suicidal Risk Associated With Finasteride Versus Dutasteride Among Men Treated for Benign Prostatic Hyperplasia: Nationwide Cohort Study Scientific Reports · 2023
    18. Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide JAMA network open · 2022
    19. Clinical and Metabolic Characteristics of Males With Early-Onset Androgenetic Alopecia PubMed · 2022
    20. A Community-Oriented Survey on the Association Between Androgenetic Alopecia and Metabolic Syndrome in Chinese People Frontiers in Medicine · 2022
    21. Case Report: A Study of the Clinical Characteristics and Genetic Variants of Post-Finasteride Syndrome Patients Translational Andrology and Urology · 2022
    22. Androgenetic Alopecia: What Impact Does It Have on the Quality of Life? Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria · 2022
    23. Are Finasteride-Related Penile Curvature/Peyronie’s Disease Adverse Event Reports Worthy of Further Clinical Investigation? Disproportionality Analysis Based on Both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) Pharmacovigilance Databases International Journal of Impotence Research · 2022
    24. Association Between Androgenetic Alopecia and Psychosocial Disease Burden: A Cross-Sectional Survey Among Polish Men Dermatology Research and Practice · 2022
    25. How Routine Pharmacovigilance Failed to Identify Finasteride’s Persistent Sexual Side Effects International Journal of Andrology · 2021
    26. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    27. Antioxidant and Antiproliferative Activity of Finasteride Against Glioblastoma Cells Pharmaceutics · 2021
    28. Antiandrogen Therapy in Hidradenitis Suppurativa: Finasteride for Females Clinical and Experimental Dermatology · 2021
    29. Differential Gene Expression in Post-Finasteride Syndrome Patients The Journal of Sexual Medicine · 2021
    30. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    31. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    32. Alterations of Gut Microbiota Composition in Post-Finasteride Patients: A Pilot Study Journal of Endocrinological Investigation · 2020
    33. Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia Anais Brasileiros De Dermatologia · 2020
    34. Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date Drug Design Development and Therapy · 2020
    35. Prescribing Habits for Androgenic Alopecia Among Dermatologists in Spain in 2019–2020: A Cross-Sectional Study Skin appendage disorders · 2020
    36. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm The World Journal of Men's Health · 2020
    37. Finasteride and Suicide: A Postmarketing Case Series Dermatology · 2020
    38. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    39. Protective Effects of Finasteride Against Testosterone-Induced Calcium Oxalate Crystallization and Crystal-Cell Adhesion Journal of Biological Inorganic Chemistry · 2019
    40. Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage: An Experimental Animal Study International Journal of Environmental Research and Public Health · 2019
    41. Incidence of Type 2 Diabetes Mellitus in Men Receiving Steroid 5α-Reductase Inhibitors: Population-Based Cohort Study BMJ. British medical journal · 2019
    42. Finasteride for Androgenetic Alopecia Is Not Associated with Sexual Dysfunction: A Survey-Based, Single-Centre, Controlled Study Journal of The European Academy of Dermatology and Venereology · 2019
    43. The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption Current Sexual Health Reports · 2018
    44. Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Sides of the Same Coin? Endocrine · 2018
    45. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    46. Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
    47. Post-Finasteride Syndrome: About 2 Cases and Review of the Literature Andrology · 2016
    48. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    49. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    50. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    51. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    52. Male Androgenetic Alopecia Human health handbooks · 2012
    53. Hair Loss in Women: Medical and Cosmetic Approaches to Increase Scalp Hair Fullness British Journal of Dermatology · 2011
    54. Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2000
    55. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997