Case Report: A Study of the Clinical Characteristics and Genetic Variants of Post-Finasteride Syndrome Patients

    September 2022 in “ Translational Andrology and Urology ”
    Xiaogang Li, Ye Guo, Yi Lu, Haolong Li, Songxin Yan, Hongjun Li, Yongzhe Li
    TLDR Finasteride may cause lasting sexual and mental health issues, and genetic screening could help prevent them.
    This case report examines three young men (aged 22-23) who developed post-finasteride syndrome (PFS) after using finasteride for androgenetic alopecia, experiencing persistent sexual and mental health side effects such as erectile dysfunction, anxiety, depression, and insomnia. Physical examinations revealed reduced testicle size in two cases, and laboratory tests showed hormonal imbalances. Genetic analysis identified five potential risk genes (CA8, VSIG10L2, HLA-B, KRT38, and HLA-DRB1) associated with PFS. The study underscores the need for further research on the long-term side effects of finasteride and suggests genetic screening as a future preventive measure, though the small sample size and lack of a control group limit the conclusions.
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      community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

      in Research/Science  9 upvotes 3 months ago
      Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

      community Why do so many people trash on finasteride?

      in Chat  247 upvotes 1 month ago
      Finasteride is effective for hair regrowth, especially on the crown, but can cause side effects like reduced libido and erectile dysfunction in some users. Opinions are mixed, with some reporting positive results without side effects and others experiencing significant issues.

      community Anyone else growing tired of the finasteride wars?

      in Finasteride/Dutasteride  169 upvotes 1 year ago
      The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

      community 1 month of using fin, so happy

      in Progress Pictures  867 upvotes 7 months ago
      User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hair growth improvement.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

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