Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

    April 2024 in “ Journal of psychiatric research ”
    R.B. Sasibhushana, B.S. Shankaranarayana Rao, Bettadapura N. Srikumar
    Studysummary This study observed that short-term administration of finasteride in male Wistar rats induced anxiety-like and depression-like behaviors, impaired spatial learning and memory, and reduced synaptic plasticity in the hippocampus, with a trend of increased corticosterone levels noted.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 15

    1. Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Clinically Similar Conditions Frontiers in Neuroendocrinology · 2023
    2. The Post-Finasteride Syndrome: Possible Etiological Mechanisms and Symptoms International journal of impotence research · 2023
    3. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    4. Sex-Specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids Cerebral cortex · 2019
    5. Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats Behavioural Brain Research · 2019
    6. The Influence of Finasteride on Mean and Relative Spectral Density of EEG Bands in a Rat Model of Thioacetamide-Induced Hepatic Encephalopathy Neurotoxicity Research · 2016
    7. 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes Endocrinology · 2015
    8. Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy American Journal of Physiology-gastrointestinal and Liver Physiology · 2014
    9. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    10. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    11. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    12. Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice Neuroscience · 2007
    13. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    14. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    15. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002

    Related research 7

    1. Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year Journal of The American Academy of Dermatology · 2020
    2. Clinical Observation on Acne Patients Taking Finasteride China Medical Abstract of Dermatology · 2013
    3. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    4. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    5. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    6. Galenic-Pharmaceutical Study of Pieces of Proscar (Finasteride 5mg) and Finasteride 1mg Capsules Versus Propecia in the Treatment of Androgenetic Alopecia Hair transplant forum international · 2000
    7. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995