Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

November 2014 in “ American Journal of Physiology-gastrointestinal and Liver Physiology ”

Dušan Mladenović, Dragan Hrnčić, Nataša Petronijević, Goran Jevtić, Tatjana Radosavljević, Aleksandra Rašić-Marković, Nela Puškaš, Nebojša Maksić, Olivera Stanojlović

finasteride Propecia

TLDR Finasteride helps brain function in rats with liver-related brain issues.

The study investigated the effects of finasteride on motor, EEG, and cellular changes in rat brains with thioacetamide-induced hepatic encephalopathy. The results showed that finasteride improved motor function, reduced EEG abnormalities, and decreased lipid peroxidation in the brain. The study suggests that finasteride may have a therapeutic effect on hepatic encephalopathy.

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Related Research

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research Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

17 citations, November 2014 in “American Journal of Physiology-gastrointestinal and Liver Physiology”

Finasteride helps brain function in rats with liver-related brain issues.

Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

Research cited in this study

research Finasteride-Related Leydig Cell Tumor: Report of a Case and Literature Review

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

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research Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy