Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

    August 2014 in “ American Journal of Physiology-gastrointestinal and Liver Physiology ”
    Dušan Mladenović, Dragan Hrnčić, Nataša Petronijević … Olivera Stanojlović
    Studysummary This study found that finasteride significantly improved motor, EEG, and cellular changes in a rat model of thioacetamide-induced hepatic encephalopathy and prevented the development of hepatic coma.
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    Research cited in this study 10

    1. Finasteride-Related Leydig Cell Tumor: Report of a Case and Literature Review Andrologia · 2011
    2. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    3. Increase in Formalin-Induced Tonic Pain by 5α-Reductase and Aromatase Inhibition in Female Rats Pharmacology Biochemistry and Behavior · 2010
    4. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    5. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    6. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    7. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    8. Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids Alcohol · 2005
    9. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004
    10. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997

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    1. Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy American Journal of Physiology-gastrointestinal and Liver Physiology · 2014