Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

November 2014 in “ American Journal of Physiology-gastrointestinal and Liver Physiology ”

Dušan Mladenović, Dragan Hrnčić, Nataša Petronijević, Goran Jevtić, Tatjana Radosavljević, Aleksandra Rašić-Marković, Nela Puškaš, Nebojša Maksić, Olivera Stanojlović

finasteride Propecia

TLDR Finasteride helps brain function in rats with liver-related brain issues.

The study investigated the effects of finasteride on motor, EEG, and cellular changes in rat brains with thioacetamide-induced hepatic encephalopathy. The results showed that finasteride improved motor function, reduced EEG abnormalities, and decreased lipid peroxidation in the brain. The study suggests that finasteride may have a therapeutic effect on hepatic encephalopathy.

View this study on journals.physiology.org →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Finasteride-Related Leydig Cell Tumor: Report of a Case and Literature Review

5 citations, May 2012 in “Andrologia”

Finasteride use may be linked to rare testicular tumor, but more research needed.

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

72 citations, January 2011 in “Current Pharmaceutical Design”

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations, December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

152 citations, October 2010 in “Archives of Dermatology”

Finasteride helps hair growth but may cause sexual side effects.

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations, September 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

54 citations, August 2005 in “Alcohol”

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

98 citations, April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Related Research

1 / 1 results

research Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

17 citations, November 2014 in “American Journal of Physiology-gastrointestinal and Liver Physiology”

Finasteride helps brain function in rats with liver-related brain issues.

Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy

Research cited in this study

research Finasteride-Related Leydig Cell Tumor: Report of a Case and Literature Review

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

Related Community Posts Join

community A little inspiration for my 18 year old balders. Left is 18 year old me right one is 24 year old me. Only propecia 1 mg daily never miss it.

community Father trying to save his 17 year old son from MPB

community Good hair days; finastride

community If you’re sitting there wondering, “I’m losing my hair, what do I do?” then read my advice here. I’ve been fighting the fight for 7 years, with great success. (pictures included)

community To anyone starting their hair loss battles. [Sorry for long post]

community Guide To Finasteride and Avoiding Side Effects

Related Research

research Finasteride Improves Motor, EEG, and Cellular Changes in Rat Brain in Thioacetamide-Induced Hepatic Encephalopathy