Sex-Specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids

    October 2019 in “ Cerebral cortex ”
    Nicola Brandt, Ricardo Vierk, Lars Fester … Gabriele M. Rune
    Studysummary This study found that testosterone and dihydrotestosterone are crucial for synaptic transmission and spine density in male hippocampal neurons, suggesting sex-specific effects of neurosteroids on brain development.
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    Research cited in this study 2

    1. Neo-Synthesis of Estrogenic or Androgenic Neurosteroids Determine Whether Long-Term Potentiation or Depression Is Induced in Hippocampus of Male Rat Frontiers in Cellular Neuroscience · 2015
    2. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006

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