Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies

    May 2024 in “ Journal of clinical medicine ”
    S. Morteza Seyed Jafari, Kristine Heidemeyer, Robert E. Hunger, Pierre A. de Viragh
    Studysummary This review assessed the safety of oral antiandrogen treatments for female androgenetic alopecia, finding spironolactone to be potentially safe even in high-risk populations, but indicated ongoing uncertainty regarding other medications, especially for patients with a history of gynecologic cancers.
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    Research cited in this study 36

    1. Hair Regrowth in Endocrine Therapy Alopecia With Dutasteride Treatment in Women With Estrogen Positive Breast Cancer JAAD case reports · 2023
    2. Association of Spironolactone Use With Risk of Cancer: A Systematic Review and Meta-Analysis JAMA Dermatology · 2022
    3. Bicalutamide and the New Perspectives for Female Pattern Hair Loss Treatment: What Dermatologists Should Know Journal of Cosmetic Dermatology · 2022
    4. Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors JAMA Dermatology · 2021
    5. Use of High-Dose Cyproterone Acetate and Risk of Intracranial Meningioma in Women: Cohort Study BMJ · 2021
    6. Spironolactone and Breast Cancer: Fear Not! Journal of the American Academy of Dermatology · 2020
    7. Spironolactone Use Does Not Increase the Risk of Female Breast Cancer Recurrence: A Retrospective Analysis Journal of The American Academy of Dermatology · 2020
    8. Bicalutamide: A Potential New Oral Antiandrogenic Drug for Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    9. Safety of Oral Bicalutamide in Female Pattern Hair Loss: A Retrospective Review of 316 Patients Journal of The American Academy of Dermatology · 2020
    10. Effectiveness and Safety of Oral Dutasteride for Male Androgenetic Alopecia in Real Clinical Practice: A Descriptive Monocentric Study Dermatologic Therapy · 2019
    11. Miscellaneous Exogenous Hormones and Breast Diseases: A Matter of Concern for the Gynecologist Archives of breast cancer · 2019
    12. Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia Clinical Breast Cancer · 2019
    13. Finasteride Use and Risk of Male Breast Cancer: A Case-Control Study Using Individual-Level Registry Data from Denmark, Finland, and Sweden Cancer Epidemiology, Biomarkers & Prevention · 2019
    14. Safety of 5α-Reductase Inhibitors and Spironolactone in Breast Cancer Patients Receiving Endocrine Therapies Breast Cancer Research and Treatment · 2018
    15. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    16. 5α-Reductase Isozymes and Aromatase mRNA Levels in Plucked Hair from Young Women with Female Pattern Hair Loss Archives of Dermatological Research · 2017
    17. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    18. Hormonal Therapy in Female Pattern Hair Loss International Journal of Women's Dermatology · 2017
    19. Evidence-Based Approach to Cutaneous Hyperandrogenism in Women Journal of The American Academy of Dermatology · 2015
    20. Long-Term Use of 5α-Reductase Inhibitors and the Risk of Male Breast Cancer Cancer Causes & Control · 2014
    21. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    22. Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients Journal of The American Academy of Dermatology · 2014
    23. Aromatase Inhibitors Induce Male Pattern Hair Loss in Women Annals of Oncology · 2013
    24. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    25. Prospective Cohort Study on the Effects and Tolerability of Flutamide in Patients with Female Pattern Hair Loss Annals of Pharmacotherapy · 2011
    26. Treatment of Female Pattern Hair Loss with the Androgen Receptor Antagonist Flutamide Australasian Journal of Dermatology · 2011
    27. Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome British Journal of Dermatology · 2010
    28. Finasteride and Male Breast Cancer: Does the MHRA Report Show a Link? PubMed · 2010
    29. Female Pattern Hair Loss May Be Triggered by Low Estrogen to Androgen Ratio PubMed · 2008
    30. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    31. Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss British Journal of Dermatology · 2001
    32. Role of Androgens in Female-Pattern Androgenetic Alopecia, Either Alone or Associated with Other Symptoms of Hyperandrogenism Archives of Dermatological Research · 2000
    33. Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2000
    34. Treatment of Hair Loss The New England Journal of Medicine · 1999
    35. Diffuse Female Hair Loss: Are Androgens Necessary? British Journal of Dermatology · 1999
    36. Testosterone Metabolism in the Skin Archives of dermatology · 1975

    Related research 2

    1. The Antiandrogens Dermatologic Clinics · 1993
    2. The Antiandrogens: When And How They Should Be Used PubMed · 1993