Bicalutamide and the New Perspectives for Female Pattern Hair Loss Treatment: What Dermatologists Should Know

    January 2022 in “ Journal of Cosmetic Dermatology ”
    Raquel de Melo Carvalho, Leopoldo Duailibe Nogueira Santos, Paulo Müller Ramos, Carla Jorge Machado, Patricia Lovatel Acioly, Simone Carolina Frattini, Carlos Baptista Barcaui, André Donda, Daniel Melo
    Image of study
    TLDR Bicalutamide, a drug with a good safety profile, is a promising new treatment for female pattern hair loss.
    The document discusses Female pattern hair loss (FPHL), the most common form of alopecia in women, which can negatively impact quality of life. Currently, the only FDA approved drug for its treatment is topical minoxidil, which has a variable response rate. However, recent studies have pointed out bicalutamide as a promising new treatment for FPHL. Bicalutamide is an emergent selective androgen receptor antagonist with a favorable safety and tolerability profile. It has no diuretic effect, does not cross the blood-brain barrier, and has little effect on serum luteinizing hormone. It was found to be effective on women presenting with other features of hyperandrogenism such as seborrhea, acne, and hirsutism with mild and well-tolerated adverse effects. Despite the high prevalence and psychosocial impairment, FPHL treatment remains challenging. Therefore, although future prospective, comparative, randomized clinical trials are essential to establish the ideal dose and efficacy of the drug, oral bicalutamide appears to be a promising option to expand the arsenal of FPHL treatment.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 102 results

      community bicalutamide or spironolactone for fphl

      in Female  6 upvotes 2 years ago
      Bicalutamide and spironolactone are being compared for their effectiveness and safety in treating female pattern hair loss. The conversation seeks advice on which is better to use.

      community Spironolactone or bicalutamide prescription

      in Treatment  4 upvotes 1 year ago
      The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

      community Goodbye y'all, it's been a journey but have accepted where I'm at

      in Update  219 upvotes 1 year ago
      The conclusion of this conversation about hair loss is that the user, y00sh420, tried various treatments including a $700 lllt helmet, topical minoxidil and finasteride, spectraDNC, and micro needling, but did not achieve the desired results. They have decided to stop trying until a cure for male pattern baldness is found. Other users expressed different opinions on hair loss treatments.

      community C’est terrible - at my wits end

      in Female  445 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

    Related Research

    9 / 9 results