Bicalutamide and the New Perspectives for Female Pattern Hair Loss Treatment: What Dermatologists Should Know

January 2022 in “ Journal of Cosmetic Dermatology ”

Raquel de Melo Carvalho, Leopoldo Duailibe Nogueira Santos, Paulo Müller Ramos, Carla Jorge Machado, Patricia Lovatel Acioly, Simone Carolina Frattini, Carlos Baptista Barcaui, André Donda, Daniel Melo

bicalutamide female pattern hair loss FPHL minoxidil androgen receptor antagonist hyperandrogenism seborrhea acne hirsutism Rogaine

From the encyclopedia

Bicalutamide →

a nonsteroidal anti-androgen, most commonly used orally for women

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This review highlights bicalutamide as a promising oral therapy for female pattern hair loss, noting its safety, tolerability, and effectiveness in women with hyperandrogenic symptoms like acne and hirsutism, though further trials are needed to confirm its ideal dose and efficacy.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

9 / 9 results

research Hormonal Effects on Hair Follicles

102 citations , July 2020 in “International journal of molecular sciences”

This review discusses the effects of hormonal changes on hair follicles, concluding that hormones like androgens and estradiol significantly influence hair growth and cycle, while the roles of other hormones are still being researched.

research Bicalutamide: A Potential New Oral Antiandrogenic Drug for Female Pattern Hair Loss

8 citations , April 2020 in “Journal of The American Academy of Dermatology”

This article discusses the potential of oral bicalutamide as a promising treatment for female pattern hair loss and reports no new clinical results.

research Safety of Oral Bicalutamide in Female Pattern Hair Loss: A Retrospective Review of 316 Patients

16 citations , March 2020 in “Journal of The American Academy of Dermatology”

This abstract discusses the efficacy of spironolactone, cyproterone acetate, and flutamide in treating female pattern hair loss, noting that flutamide use requires caution due to potential liver toxicity, especially at high doses.

research Female Pattern Hair Loss: An Update

12 citations , January 2020 in “Indian Dermatology Online Journal”

This article discusses the causes, diagnosis, and treatment options for female pattern hair loss, emphasizing the role of topical minoxidil as a primary treatment, but provides no new clinical results.

research Oral Bicalutamide for Female Pattern Hair Loss: A Pilot Study

8 citations , October 2019 in “Dermatologic Therapy”

This source explores the potential use of oral bicalutamide for treating female pattern hair loss, but specific results or outcomes from the study are not reported in the abstract.

Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial

research Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial

25 citations , December 2017 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that using an oral contraceptive with bicalutamide significantly reduced hirsutism in women with PCOS compared to an oral contraceptive alone, although it increased total cholesterol and LDL levels.

research Interventions for Female Pattern Hair Loss

35 citations , May 2012 in “Cochrane Database of Systematic Reviews”

This review found evidence supporting the effectiveness and safety of topical minoxidil for treating female pattern hair loss, though many included studies were at high risk of bias.

research Prospective Cohort Study on the Effects and Tolerability of Flutamide in Patients with Female Pattern Hair Loss

42 citations , April 2011 in “Annals of Pharmacotherapy”

This study found that long-term flutamide treatment reduced hair loss in women with female pattern hair loss, but liver-related dropouts were minimized at a very low dose of 62.5 mg/day.

research Treatment of Hyperandrogenic Alopecia in Women

108 citations , January 2003 in “Fertility and Sterility”

This study found that flutamide at 250 mg daily modestly improved hair thinning in premenopausal women with hyperandrogenic alopecia over one year, while cyproterone acetate and finasteride were not effective.