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    Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial

    December 2017 in “ The Journal of Clinical Endocrinology & Metabolism ”
    Costanzo Moretti, Laura Guccione, Paola Di Giacinto … Andrea Lenzi
    Studysummary This study found that using an oral contraceptive with bicalutamide significantly reduced hirsutism in women with PCOS compared to an oral contraceptive alone, although it increased total cholesterol and LDL levels.
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    Research cited in this study 19

    1. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016
    2. Interventions for Hirsutism Excluding Laser and Photoepilation Therapy Alone: Abridged Cochrane Systematic Review Including GRADE Assessments British journal of dermatology/British journal of dermatology, Supplement · 2016
    3. American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1 Endocrine Practice · 2015
    4. The Polycystic Ovary Syndrome: A Position Statement from the European Society of Endocrinology European Journal of Endocrinology · 2014
    5. Therapy of Endocrine Disease: Treatment of Hirsutism in Polycystic Ovary Syndrome European journal of endocrinology · 2013
    6. Update on Idiopathic Hirsutism: Diagnosis and Treatment Acta Clinica Belgica · 2013
    7. The Role of Androgen and Androgen Receptor in Skin-Related Disorders Archives of Dermatological Research · 2012
    8. Hepatotoxicity with Low- and Ultralow-Dose Flutamide: A Surveillance Study on 203 Hyperandrogenic Young Females Fertility and Sterility · 2012
    9. 5 mg/Day Finasteride Treatment for Normoandrogenic Asian Women with Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2010
    10. Visually Scoring Hirsutism Human reproduction update · 2009
    11. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    12. Dermoscopy in Female Androgenic Alopecia: Method Standardization and Diagnostic Criteria International Journal of Trichology · 2009
    13. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008
    14. Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2008
    15. Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle Journal of Investigative Dermatology Symposium Proceedings · 2005
    16. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003
    17. Comparison of Diane 35 and Diane 35 Plus Finasteride in the Treatment of Hirsutism Fertility and Sterility · 2000
    18. Management of Hirsutism American journal of clinical dermatology · 2000
    19. Finasteride The New England Journal of Medicine · 1994