Miscellaneous Exogenous Hormones and Breast Diseases: A Matter of Concern for the Gynecologist

    November 2019 in “ Archives of breast cancer ”
    Sadaf Alipour, Amirhossein Eskandari
    From the encyclopedia
    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    Dutasteride →

    Heavy duty finasteride that comes with higher risks

    Spironolactone →

    powerful topical and oral anti-androgen used mostly by women

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    Studysummary This review discusses non-oral hormonal contraceptives and other exogenous steroid hormones, reporting they are generally safe for temporary use in women without breast cancer, but data are limited.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This 2019 review examined the potential links between various exogenous hormones and breast diseases, particularly breast cancer. It suggested that hormone replacement therapy (HRT) might increase the risk of breast cancer, with some studies indicating a dose-response relationship. On the other hand, the use of the levonorgestrel-releasing intrauterine system was associated with a decreased risk of ovarian and endometrial cancer, without an increased risk of breast cancer. The review also explored the potential breast cancer risks associated with other hormonal treatments, such as megestrol acetate, ethinyl estradiol, cyproterone acetate, finasteride, dutasteride, and spironolactone, with conclusions varying based on the studies cited.
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