Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage: An Experimental Animal Study

May 2019 in “ International Journal of Environmental Research and Public Health ”

Mirza Wasif Baig, Agnieszka Kolasa, Anna Pilutin, Krzysztof Safranow, Irena Baranowska-Bosiacka, Joanna Kabat-Koperska, Barbara Wiszniewska

finasteride 5α-reductase type 2 androgen receptor intracellular junctional proteins DHT androgen supplementation renal dysfunction renal transplantation Propecia dihydrotestosterone kidney disease

Studysummary This study found that finasteride treatment in male rats altered steroid hormone homeostasis and caused kidney damage, suggesting potential risks for patients with renal dysfunction on androgen or antiandrogen therapy.

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research Connexin 43 Expression in the Testes During Postnatal Development of Finasteride-Treated Male Rat Offspring

3 citations , February 2017 in “Archives of Medical Science”

This study found that finasteride treatment in male rats may lead to changes in connexin 43 expression in the testes of their offspring, potentially affecting spermatogenesis.

research Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring

10 citations , September 2015 in “Folia Histochemica Et Cytobiologica”

This study found that paternal exposure to finasteride in male rats may impair fertility and affect androgen-sensitive spermatogenesis in their male offspring.

research DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

research Effects of Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells

25 citations , December 2008 in “The Journal of Urology”

In this study, short-term finasteride treatment reduced apoptotic factors caspase-7 and IGFBP-3 in prostate cancer cells but did not significantly affect androgen receptor expression compared to placebo.

Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

research Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

77 citations , October 2007 in “International Journal of Andrology”

This study found that testosterone replacement, with or without finasteride, did not lead to significant cognitive improvements over 36 months in healthy older men without prior cognitive impairment.

research Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities

51 citations , February 2004 in “Environmental Health Perspectives”

This article analyzes various cases of weak or low-dose endocrine effects in laboratory animals and highlights challenges in data interpretation due to variability among controls, but reports no new experimental findings.

research Exogenous Testosterone or Testosterone with Finasteride Increases Bone Mineral Density in Older Men with Low Serum Testosterone

417 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that testosterone therapy increased bone mineral density in older men with low testosterone, and combining it with finasteride may reduce prostate enlargement associated with testosterone treatment.

research Long-Term Multinational Experience with Finasteride 1 mg in the Treatment of Men with Androgenetic Alopecia

20 citations , April 2002 in “PubMed”

This study found that long-term treatment with finasteride 1 mg/day significantly improved scalp hair growth and was well tolerated in men with androgenetic alopecia over five years compared to placebo.

research Contribution of Androgens to Chronic Allograft Nephropathy Is Mediated by Dihydrotestosterone

25 citations , November 2001 in “Kidney International”

This study suggests that dihydrotestosterone plays a key role in the development of chronic allograft nephropathy, and inhibiting androgens may improve long-term kidney transplant outcomes.

research Finasteride

125 citations , January 1999 in “Drugs”

This study found that oral finasteride 1 mg/day promotes hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss over two years.

research Finasteride

86 citations , July 1993 in “Drugs”

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.