Are Finasteride-Related Penile Curvature/Peyronie’s Disease Adverse Event Reports Worthy of Further Clinical Investigation? Disproportionality Analysis Based on Both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) Pharmacovigilance Databases

    Nicolò Schifano, Paolo Capogrosso, Luca Boeri … Andrea Salonia
    Studysummary This pharmacovigilance study found strong disproportionality signals suggesting an association between finasteride and Peyronie's disease-related clinical features, but the evidence does not confirm a causal link.
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    Research cited in this study 12

    1. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    2. Post-Finasteride Syndrome BMJ · 2019
    3. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome Urology · 2018
    4. A Comment on the Post-Finasteride Syndrome International Journal of Trichology · 2018
    5. Androgenetic Alopecia: A Review Endocrine · 2017
    6. Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia Sexual Medicine · 2016
    7. Post-Finasteride Syndrome: About 2 Cases and Review of the Literature Andrology · 2016
    8. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    9. Hair Restoration Approaches for Early Onset Male Androgenetic Alopecia Journal of Cosmetic Dermatology · 2013
    10. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    11. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    12. Improvement in Androgenetic Alopecia in 53-76-Year-Old Men Using Oral Finasteride International Journal of Dermatology · 1999

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