A Comment on the Post-Finasteride Syndrome

    January 2018 in “ International Journal of Trichology ”
    Hudson Dutra Rezende, Maria Inês Dias, Ralph M. Trüeb
    Studysummary This commentary reviews the post-Finasteride syndrome and argues that while the condition's validity is debated, comprehensive guidelines are needed to address related risks and treatment options; it reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 41

    1. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    2. A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women PubMed · 2018
    3. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss The Journal of Clinical Endocrinology and Metabolism · 2016
    4. Discriminating in Favor of or Against Men with Increased Risk of Finasteride-Related Side Effects? Experimental Dermatology · 2016
    5. Are Hand Preference And Sexual Orientation Possible Predicting Factors For Finasteride Adverse Effects In Male Androgenic Alopecia? Experimental Dermatology · 2016
    6. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    7. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016
    8. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    9. Finasteride, Not Tamsulosin, Increases Severity of Erectile Dysfunction and Decreases Testosterone Levels in Men With Benign Prostatic Hyperplasia Hormone Molecular Biology and Clinical Investigation · 2015
    10. Tackling Adverse Effects 2015
    11. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia PLOS ONE · 2014
    12. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    13. Effect of Dutasteride 0.5 mg/day in Men with Androgenetic Alopecia Recalcitrant to Finasteride International Journal of Dermatology · 2014
    14. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    15. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    16. Finasteride and Fertility: Case Report and Review of the Literature PubMed · 2012
    17. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    18. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    19. Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia Journal of Dermatology · 2011
    20. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    21. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    22. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    23. Finasteride Induced Gynecomastia: Case Report and Review of the Literature International Journal of Trichology · 2009
    24. Long-Term Treatment with Finasteride 1 mg Decreases the Likelihood of Developing Further Visible Hair Loss in Men with Androgenetic Alopecia PubMed · 2008
    25. Propecia-Induced Spermatogenic Failure: A Report of Two Cases Fertility and Sterility · 2007
    26. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    27. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    28. Changes in Hair Weight in Men with Androgenetic Alopecia After Treatment with Finasteride (1 mg Daily): Three- and Four-Year Results Journal of The American Academy of Dermatology · 2006
    29. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    30. Efficacy and Tolerability of Finasteride 1 mg in Men Aged 41 to 60 Years with Male Pattern Hair Loss PubMed · 2003
    31. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    32. Long-Term Multinational Experience with Finasteride 1 mg in the Treatment of Men with Androgenetic Alopecia PubMed · 2002
    33. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
    34. Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women Journal of Investigative Dermatology Symposium Proceedings · 1999
    35. Improvement in Androgenetic Alopecia in 53-76-Year-Old Men Using Oral Finasteride International Journal of Dermatology · 1999
    36. Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men The Journal of Urology · 1999
    37. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    38. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    39. Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia Dermatologic Clinics · 1996
    40. Personality Disorders and Psychopathologic Symptoms in Patients With Androgenetic Alopecia Archives of Dermatology · 1994
    41. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992

    Related research 10

    1. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022
    2. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    3. Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review Skin appendage disorders · 2020
    4. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    5. A Comment on the Post-Finasteride Syndrome International Journal of Trichology · 2018
    6. Interventions for Female Pattern Hair Loss JAMA Dermatology · 2017
    7. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    8. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    9. Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia Journal of Dermatology · 2011
    10. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004